Panniculitis - Pannikulit
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References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis teri osti yog 'to'qimasini o'z ichiga olgan yallig'lanish kasalliklarining heterojen guruhini tashkil qiladi. Bolalarda bunday buzilishlar kam uchraydi. Pannikulit tizimli kasallikdagi asosiy jarayon yoki infektsiya, travma yoki dori ta'siridan kelib chiqadigan ikkilamchi jarayon bo'lishi mumkin. Pannikulitning aksariyat turlari bir xil klinik ko'rinishga ega (etiologiyasidan qat'iy nazar) , teri osti teri osti tugunlari nozik, eritematoz.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , teri osti yog'ining yallig'lanishi, odatda yallig'lanish tugunlari bilan namoyon bo'ladi. Erythema nodosum (EN) klinik jihatdan pannikulitning eng keng tarqalgan shakli hisoblanadi. EN ning 55% i idiopatik deb hisoblansa-da, eng ko'p uchraydigan sabablarga infektsiyalar, dorilar, sarkoidoz va yallig'lanishli ichak kasalliklari, homiladorlik va malign o'smalar kabi tizimli kasalliklar kiradi. EN odatda o'smirlar va 20 yoshda namoyon bo'ladi va ko'proq ayollarda kuzatiladi. Ko'pincha undan oldin bir haftadan uch haftagacha bo'lgan o'ziga xos bo'lmagan prodrom paydo bo'ladi, bu isitma, bezovtalik va yuqori nafas yo'llari infektsiyasining alomatlarini o'z ichiga olishi mumkin. Keyin teri lezyonlari kuzatiladi, odatda oyoq-qo'llarning ekstansor tomonida lokalizatsiya qilinadi. Yaralar og'riqli yumaloq yoki oval, biroz ko'tarilgan, yarasiz qizil tugunlardir. EN ning aniq patogenezi tushunilmagan, ammo neytrofil pannikulitni keltirib chiqaradigan teri osti yog 'parchalari venulalarida immun komplekslarning cho'kishi natijasida yuzaga keladi deb taxmin qilinadi. Qo'zg'atuvchi holat uchun o'ziga xos terapiyasiz ham, EN ko'p hollarda davolanmasdan o'tib ketadi.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
"Eritema nodosum" pannikulit (panniculitis) ning bir shakli bo'lib, 1-10 sm uzunlikdagi nozik qizil tugunlar bilan xarakterlanadi, tizimli simptomlar, jumladan isitma, bezovtalik va bo'g'imlardagi og'riqlar bilan bog'liq. Nodullar 2-6 hafta davomida yara yoki chandiqsiz tushishi mumkin. Eritema nodosum infektsiyalari, jumladan gepatit C, EBV va sil, homiladorlik, non-Hodgkin limfomasi va oshqozon osti bezi saratoni bilan bog'liq.