Porokeratosis - Porokeratoz
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Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Qattiq chiqadigan qirralar xarakterlidir.
relevance score : -100.0%
ReferencesPorokeratoz (Porokeratosis) teridagi kamdan‑kam uchraydigan holat bo‘lib, keratinizatsiya muammolari bilan tavsiflanadi, natijada terida ko‘tarilgan, halqa shaklidagi yamalar yoki qattiq bo‘laklar paydo bo‘ladi. Mikroskop ostida uning belgilovchi xususiyati teri ustki qatlamidagi hujayralarning o‘ziga xos joylashuvi bo‘lgan kornoid lamella (cornoid lamella) mavjudligidir. Porokeratoz turli shakllarda keladi, masalan, tarqalgan sirtki aktinik porokeratoz (disseminated superficial actinic porokeratosis), klassik Mibelli porokeratoz (classical porokeratosis of Mibelli), palmar‑plantar porokeratoz (porokeratosis palmaris plantaris et disseminatum), va chiziqli porokeratoz (linear porokeratosis). Shuni ta’kidlash kerakki, porokeratoz teri saratoniga aylanishi mumkin. Porokeratoz tashxisining eng yaxshi usuli bu ko‘tarilgan chegaraning biopsiyasidir, ammo hozirda standart davolash protokoli mavjud emas.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) – keratinizatsiyaning buzilishi kasalligi. Bu porokeratozning olti turidan biri bo‘lib, odatda boshqalarga qaraganda kattaroq joylarga ta’sir qiladi (linear, Mibelli’s, punctate, palmoplantar disseminated, and superficial porokeratosis). Porokeratozning eruptiv turi ko‘pincha saraton, immunosupressiya (immunosuppression) yoki yallig‘lanish bilan bog‘liq. Xavf omillariga genetika, immunosupressiya (immunosuppression) va ultraviyole nurlanish (ultraviolet light) kiradi. DSAP quyosh nuri ta’sir qiladigan joylarda ko‘tarilgan qirralari bo‘lgan pushti yoki jigarrang dog‘lar (papules and macules) shaklida boshlanadi, ba‘zan esa engil qichishishga olib keladi. Davolash usullari turlicha bo‘lib, mahalliy kremlar, fotodinamik terapiya (photodynamic therapy, PDT), 5-fluorouracil (5-FU), diclofenac, imiquimod, vitamin D analogs, retinoidlar va lazerlar kabi dori‑darmonlarni o‘z ichiga olishi mumkin. Ushbu lezyonlar skuamoz hujayrali karsinoma (squamous cell carcinoma) yoki bazal hujayrali karsinoma (basal cell carcinoma) ga aylanish ehtimoli 7.5‑10 % bo‘lgan prekanseroz hisoblanadi.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
52 yoshli, avvallari sog‘lom, to‘rtinchi barmog‘ining distal qismida 2 yil davomida belgilarsiz, halqasimon atrofik dog bilan keldi. U kichik keratotik papula sifatida boshlandi va vaqt o‘tishi bilan markazdan tashqariga kengayib bordi. Kriyoterapiya, topik kortikosteroid kremlar, antifungal dorilar va antibiotiklar kabi turli xil muolajalarni sinab ko‘rishga qaramay, yamoq yaxshilanmadi. Dermokopiya bilan yaqindan tekshirilganda quruq, atrofik, eritmatik markaziy zona va aniq chegaralangan periferik giperkeratotik tuzilma ko‘rsatilgan. Yamoqning chetidan olingan terining kichik bo‘lagi terining tashqi qatlamida kornoid lamella va epidermisning invaginatsiyasidan kengayib chiqqan parakeratotik hujayralar ustunligi, granulyar qatlamning yo‘qligi bilan namoyon bo‘ldi, bu Mibelli porokeratosisi tashxisini tasdiqladi.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Ko'pincha biopsiya amalga oshiriladi, chunki u aktinik keratoz yoki skuamoz hujayrali karsinomaga o'xshash bo'lishi mumkin.