Porokeratosis - Porokeratoz
☆ Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Qattiq chiqadigan qirralar xarakterlidir.
References
Porokeratosis teridagi kamdan-kam uchraydigan holat bo'lib, keratinizatsiya muammolari bilan tavsiflanadi, natijada terida ko'tarilgan, halqa shaklidagi yamalar yoki qo'pol bo'laklar paydo bo'ladi. Mikroskop ostida uning belgilovchi xususiyati teri ustki qatlamidagi hujayralarning o'ziga xos joylashuvi bo'lgan kornoid lamelning mavjudligidir. Porokeratosis turli shakllarda keladi, masalan, disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Shuni ta'kidlash kerakki, porokeratosis teri saratoniga aylanishi mumkin. Porokeratosis tashxisining eng yaxshi usuli bu ko'tarilgan chegaraning biopsiyasidir, ammo hozirda standart davolash protokoli mavjud emas.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) - keratinizatsiyaning buzilishi kasalligi. Bu porokeratozning olti turidan biri bo'lib, odatda boshqalarga qaraganda kattaroq joylarga ta'sir qiladi (linear, Mibelli's, punctate, palmoplantar disseminated, and superficial porokeratosis) . Porokeratozning portlovchi turi ko'pincha saraton, zaif immunitet yoki yallig'lanish bilan bog'liq. Xavf omillariga genetika, immunitetni susaytirish va quyosh ta'siri kiradi. DSAP quyosh nuri ta'sir qiladigan joylarda ko'tarilgan qirralari bo'lgan pushti yoki jigarrang dog'lar shaklida boshlanadi, ba'zan esa engil qichishishga olib keladi. Davolash usullari turlicha bo'lib, mahalliy kremlar, yorug'lik terapiyasi yoki 5-ftorurasil yoki retinoidlar kabi dori-darmonlarni o'z ichiga olishi mumkin. Ushbu lezyonlar skuamoz hujayrali yoki bazal hujayrali karsinomaga aylanish ehtimoli 7. 5 - 10 % bo'lgan prekanseroz hisoblanadi.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
52 yoshli, avvallari sog‘lom, to‘rtinchi barmog‘ining uchida 2 yil davomida hech qanday alomatsiz turgan tekis, halqasimon yamoq bilan keldi. U kichik, qattiq zarba sifatida boshlandi va vaqt o'tishi bilan tashqi tomonga o'sib bordi. Kriyoterapiya, kremlar, antifungallar va antibiotiklar kabi turli xil muolajalarni sinab ko'rishga qaramay, yamoq yaxshilanmadi. Dermokopiya bilan yaqindan tekshirilganda qalin, qo'pol chegaraga ega quruq, qizil markaz ko'rsatilgan. Yamoqning chetidan olingan terining kichkina bo'lagi terining tashqi qatlamida g'ayritabiiy hujayralar o'sishini ko'rsatdi, bu porokeratosis of Mibelli tashxisini tasdiqladi.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Ko'pincha biopsiya amalga oshiriladi, chunki u aktinik keratoz yoki skuamoz hujayrali karsinomaga o'xshash bo'lishi mumkin.