Syphilis - Sifilis
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Chancres — Treponema pallidum tomonidan keltirilgan birlamchi sifilit infektsiyasi.
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ReferencesSifilis — bu *Treponema pallidum* bakteriyasi keltirib chiqaradigan, jinsiy yo‘l orqali yuqadigan kasallik. Ushbu tadqiqotda biz 18‑68 yoshdagi, ikkilamchi sifilis tashxisi qo‘yilgan 57 nafar bemorga e’tibor qaratamiz.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sifilis – bu Treponema pallidum tomonidan qo‘zg‘atilgan bakterial infektsiya. U turli kasalliklarga taqlid qilishi mumkin va “great imitator” laqabini oladi. Sifilis hali ham butun dunyo bo‘ylab millionlab odamlarga ta’sir qiladi, ammo penicillin bilan samarali davolash mumkin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum homiladorlik paytida jinsiy aloqa orqali yoki onadan chaqaloqqa sifilisni olib keladi. Uni tashxislash uchun oddiy testlar mavjud bo'lsa‑da, bitta uzoq muddatli penicillin zarbasi bilan davolash yaxshi samara bersa ham, sifilis butun dunyo bo'ylab yana katta muammoga aylanmoqda. Bu, ayniqsa, yuqori va o'rta daromadli mamlakatlarda erkaklar bilan jinsiy aloqada bo'ladigan erkaklar (MSM) orasida ko'proq uchraydi. Ba'zi kam ta'minlangan mamlakatlar sifilisning onadan chaqaloqqa o'tishini to'xtatish bo'yicha JSST maqsadlariga erishgan bo'lsa‑da, OIV‑musbat MSMlar orasida sifilisning o'sishi xavotirli.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Kattalashgan jigar: Bu tez-tez uchraydi va kengaygan taloq bilan birga bo'lishi mumkin. Qorong'i maydon mikroskopida jigar biopsiyasini tekshirish spiroxetaning mavjudligini aniqlashi mumkin. Jigar funktsiyasi testlari anormalliklarni ko'rsatishi mumkin. (2) Terining sarg'ayishi (sariqlik): Sariqlik darajasi jigar qanchalik zarar ko'rganiga bog'liq. (3) Burun oqishi: Ko'pincha birinchi belgilardan biri bo'lib, odatda tug'ilganidan keyingi birinchi hafta ichida paydo bo'ladi. (4) Shishgan limfa tugunlari: Limfa tugunlarining umumiy shishishi, odatda og'riqsiz, keng tarqalgan. (5) Teri toshmasi: Toshma odatda burun oqishidan bir‑ikki hafta o'tgach paydo bo'ladi. Orqa, dumba, son va oyoq tagida kichik qizil yoki pushti dog'larni ko'rishingiz mumkin. Bu toshma terini qirib, qobiqka aylanadi.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnoz va davolash
VDRL va RPR testlari sifilis infektsiyasini tasdiqlash va tekshirish uchun ishlatiladi. FTA‑ABS testi aniqroq bo‘lib, oldingi infektsiya tarixini aniqlash uchun qo‘llaniladi. Penicillin sifilisni davolash uchun ishlatiladi.