Toxic epidermal necrosis - Toksik Epidermal Nekroz
☆ Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Terining xarakterli yo'qolishi Toksik Epidermal Nekroz (Toxic epidermal necrosis)
References
Stevens-Johnson Syndrome (SJS) va Toxic Epidermal Necrolysis (TEN) - terida keng nekroz va to'kilish sodir bo'ladigan kamdan-kam holatlar. Davolash nuqtai nazaridan siklosporin SJS uchun juda samarali, tomir ichiga immunoglobulin (IVIg) va kortikosteroidlar kombinatsiyasi SJS va TEN holatlarida eng yaxshi ishlaydi.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) - ba'zi dori-darmonlar va immunitet tizimining faolligi tufayli yuzaga keladigan jiddiy teri reaktsiyasi, natijada terining tashqi qatlami (epidermis) keng miqyosda ajralib chiqadi, bu tana yuzasining 30% dan ko'prog'iga ta'sir qiladi. TEN o'lim darajasi 20% dan ortiq, ko'pincha infektsiyalar va nafas olish qiyinlishuvi tufayli. Reaktsiyani keltirib chiqaradigan dori-darmonlarni to'xtatish, qo'llab-quvvatlovchi yordam ko'rsatish va qo'shimcha davolash usullaridan foydalanish natijani yaxshilashi mumkin. So'nggi tadqiqotlar shuni ko'rsatdiki, siklosporin, o'simta nekrozi omili alfa inhibitörleri va tomir ichiga yuboriladigan immun globulin va kortikosteroidlar kombinatsiyasi kabi dorilar randomize nazorat ostida sinovlar va bir nechta tadqiqotlar tahlillari asosida foydali bo'lishi mumkin.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Eng ko'p uchraydigan sabab - lamotrigin, karbamazepin, allopurinol, sulfanilamid antibiotiklari va nevirapin kabi ba'zi dorilar. Xavf omillariga OIV va tizimli qizil yuguruk kiradi. Davolash odatda shifoxonada, masalan, kuyish bo'limida yoki intensiv terapiya bo'limida amalga oshiriladi.
○ Davolash
Bu jiddiy kasallik, shuning uchun lablaringiz yoki og'zingiz ta'sirlansa yoki teringiz pufakchalar paydo bo'lsa, iloji boricha tezroq shifokoringizga murojaat qiling.
Shubhali dorilarni qabul qilishni to'xtatish kerak. (masalan, antibiotiklar, steroid bo'lmagan yallig'lanishga qarshi dorilar)