Amyloidosis - I-Amyloidosis
☆ Kwiziphumo zika-2022 ze-Stiftung Warentest ezivela eJamani, ukwaneliseka kwabathengi ngeModelDerm bekungaphantsi kancinci kunokubonisana nge-telemedicine ehlawulweyo.
Iimpawu zobuso eziqhelekileyo ze I-Amyloidosis (Amyloidosis)
References
Inkosikazi eneminyaka engama-26 ubudala yeza kwikliniki yethu ikhalaza ngokurhawuzelelwa yimilenze yayo iminyaka eyi-10. Ngaphandle kokusebenzisa i-steroid creams kunye ne-tazarotene cream, i-rash ayizange ibe ngcono. Wayengenayo imbali yosapho efanelekileyo. Sathi sakumxilonga, safumanisa ukuba kukho amabala arhabaxa ngaphambili emilenzeni yakhe, afana nesifo esibizwa ngokuba lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis yimeko yolusu enqabileyo edityaniswa nokurhawuzelelwa okuzingileyo okungaziwayo unobangela. Ngokuqhelekileyo ibonakala njengeqela leebala eziphakanyisiweyo, eziguqulwe umbala kumphezulu wolusu. Lichen Amyloidosis idla ngokuvela kubantu abaneminyaka engama-50 ukuya kuma-60 kwaye ngelishwa, akukho nyango lwalo. Unyango olukhoyo ngoku aludli ngokusebenza kakuhle.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis yimeko yolusu olurhawuzelelwa ixesha elide. Yaziwa ngamaqhuqhuva ajiyileyo afumaneka emqolo, ezinqeni, emathangeni nasezingalweni. Xa ijongwa phantsi kwemakroskopu, Lichen amyloidosis ibonisa ukwakheka kwe-amyloid kumaleko aphezulu wolusu kunye nokujiya kunye nokwandiswa kolusu lwangaphandle. Nangona oyena nobangela we Lichen amyloidosis ungekaqondwa ngokupheleleyo okwangoku, izifundo ezidlulileyo ziye zayinxulumanisa nezinto ezifana nokukhuhla okanye ukukhuhlana eluswini, ukufa kweeseli, usulelo lwentsholongwane, phakathi kwezinye. Lichen amyloidosis ibonakala inxulunyaniswe nezinye iimeko zolusu ezininzi (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Uxilongo kunye noNyango
#Electrophoresis of blood or urine
#Skin biopsy