Drug eruption
☆ Kwiziphumo zika-2022 ze-Stiftung Warentest ezivela eJamani, ukwaneliseka kwabathengi ngeModelDerm bekungaphantsi kancinci kunokubonisana nge-telemedicine ehlawulweyo.
Drug eruption ibonakala ngokuchaphazela wonke umzimba.
References
Ukuchaphazeleka kolusu okubangelwa ngamayeza, okwaziwa njengokuqhushumba kweziyobisi, ngamanye amaxesha kunokuba nzima. Ezi ntshukumo ziqatha, ezibizwa ngokuba yi severe cutaneous adverse drug reactions (SCARs) , zithathwa njengomngcipheko wobomi. Ziquka iimeko ezifana Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Ngelixa SCARs zinqabile, malunga ne-2% yezigulana ezilaliswe esibhedlele ziyahlangabezana nazo.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Ibhinqa elineminyaka engama-31 ubudala lityelele isebe le-dermatology linebala elibomvu elingenabuhlungu phezu konyawo lwasekunene. Uthathe idosi enye ye-doxycycline (100 mg) kusuku olungaphambili, elandela unyango lwe-picosecond laser lwezivubeko zamaqhakuva. Kunyaka ophelileyo, uye wafumana ingxaki efanayo kwindawo enye emva kokuthatha idosi efanayo ye-doxycycline yonyango lwasemva kwelaser. Akanayo imbali ebalulekileyo yezonyango kwaye akanazo ezinye iimpawu, njengomkhuhlane, ekuhlaleni okanye emzimbeni wakhe wonke.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) kunye toxic epidermal necrolysis (TEN) ziintlobo ezimbini zokusabela kolusu okumandundu, okwahlukileyo kwezinye iimeko zolusu ezifana ne-erythema multiforme enkulu kunye ne-staphylococcal scalded skin syndrome, kunye nokusabela kweziyobisi. SJS/TEN yindlela enqabileyo nenzima yokusabela ebangela ukonakaliswa kwesikhumba kunye nenwebu yamafinya, amaxesha amaninzi kukho iimpawu zenkqubo. Ngaphezulu kwe-80% yamatyala, amayeza abangela.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Ukuqhuma kweziyobisi kuxilongwa ikakhulu kwimbali yonyango kunye nokuhlolwa kweklinikhi. I-skin biopsy, iimvavanyo zegazi okanye iimvavanyo ze-immunological nazo zinokuba luncedo.
Imizekelo yeziyobisi eziqhelekileyo ezibangela ukuqhuma zi-antibiotics kunye nezinye iziyobisi ze-antimicrobial, i-sulfa drugs, i-nonsteroidal anti-inflammatory drugs (NSAIDs), i-chemotherapy agents for malignancies, anticonvulsants kunye ne-psychotropic drug.
○ Uxilongo kunye noNyango
Ukuba unomkhuhlane (ukunyuka kobushushu bomzimba), kufuneka ufune unyango ngokukhawuleza. Iyeza elirhanelwayo kufuneka lipheliswe (umzekelo, i-antibiotics, i-non-steroidal anti-inflammatory drugs). Ngaphambi kokutyelela esibhedlele, i-antihistamines yomlomo efana ne-cetirizine okanye i-loratadine inokunceda ukurhawuzelela kunye ne-rash.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Uvavanyo lwegazi (CBC, LFT, eosinophil count)
I-Oral steroids kunye ne-antihistamines kunye nomyalelo kagqirha