Dysplastic nevus - I-Dysplastic Nevus
☆ Kwiziphumo zika-2022 ze-Stiftung Warentest ezivela eJamani, ukwaneliseka kwabathengi ngeModelDerm bekungaphantsi kancinci kunokubonisana nge-telemedicine ehlawulweyo.
Dysplastic nevi ― Biopsy iyacetyiswa kubantu baseNtshona.
References
Dysplastic nevus , ekwaziwa njenge-atypical okanye iClarks nevus, iye yavusa iingxoxo kwidermatology kunye nedermatopathology. Oogqirha bahlala behlolisisa ezi moles kuba banokubonakala bengaqhelekanga kwaye baphakamise iinkxalabo malunga ne-melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , ekwabizwa ngokuba yi-atypical okanye iClark nevi, ngamanye amaxesha inokukhokelela kwi-melanoma. Malunga ne-36% ye-melanomas ifunyanwa kufutshane ne-dysplastic nevi. Iimpawu ezibonisa ukuba i-dysplastic nevus inokujika ibe yi-melanoma ziquka imilo engalinganiyo, utshintsho oluninzi lwebala, okanye umbala ongwevu. Le mihlaza idla ngokwenzeka besebancinci (malunga nesiqingatha seminyaka engamashumi amathathu) , inokuba ninzi, kwaye isoloko isesiqwini. Ngokwemfuza, dysplastic nevi ziphakathi kwe-benign nevi kunye ne-melanoma. Nangona kunjalo, kuphela ngama-20% ukuya kwi-30% yeemelanomas eziphuma kwi-nevi esele ikhona. Kuba iinevi ezininzi zingabi yimelanoma, akudla ngokucetyiswa ukuba ziyisuse ngothintelo.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
I-melanoma luhlobo lwethumba elenza xa i-melanocytes, iiseli ezinoxanduva lombala wolusu, ziba nomhlaza. I-Melanocytes ivela kwi-neural crest. Oku kuthetha ukuba i-melanomas ayinakukhula kuphela eluswini kodwa nakwezinye iindawo apho iiseli ze-neural crest zifuduka, njengephecana lesisu kunye nengqondo. Izinga lokusinda kwizigulane ezine-melanoma yesigaba sokuqala (inqanaba le-0) liphezulu kuma-97%, ngelixa lehla kakhulu malunga ne-10% kwabo bafunyaniswa ukuba banesifo senqanaba eliphezulu (inqanaba IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Cancer risk
Njengoko kubonakala kubantu baseCaucasus eUnited States, abo bane-dysplastic nevi banomngcipheko wobomi bonke wokuba ne-melanoma engaphezu kwe-10%. Ngakolunye uhlangothi, abo bangenayo nayiphi na i-dysplastic nevus banomngcipheko wokuphuhlisa i-melanoma engaphantsi kwe-1%.
○ Precaution kubantu abane-dysplastic nevi
Ukuzihlola ulusu ngokuqhelekileyo kuyacetyiswa ukuba kuthintelwe imelanoma (ngokuchonga i-atypical nevi enokususwa) okanye ukubhaqwa kwangethuba kwamathumba akhoyo. Abantu abanembali yobuqu okanye yosapho yomhlaza wolusu okanye abane-atypical nevi ezininzi kufuneka babonane nogqirha wesikhumba ubuncinane kanye ngonyaka ukuze baqiniseke ukuba abaphuhlisi melanoma.
Isishunqulelo [ABCDE] sibe luncedo ekuncedeni ababoneleli bezempilo kunye nabantu abaleleyo bakhumbule iimpawu eziphambili zemelanoma. Ngelishwa kumntu oqhelekileyo, uninzi lwe-seborrheic keratoses, i-lentigo senilis, kunye neentsumpa zinokuba neempawu ze- [ABCDE], kwaye azikwazi ukwahlulwa kwi-melanoma.
○ [ABCDE]
Asymmetrical: Isilonda solusu se-asymmetrical.
Border: Umda wesilonda awuqhelekanga.
Color: I-melanoma idla ngokuba nemibala emininzi engaqhelekanga.
Diameter: I-nevi enkulu kune-6 mm kunokwenzeka ukuba ibe yi-melanoma kune-nevi ezincinci.
Evolution: I-evolution (okt utshintsho) ye-nevus okanye i-lesion ingabonisa ukuba isilonda siba sibi.