Drug eruption - Oogun Eruptionhttps://en.wikipedia.org/wiki/Drug_eruption
Oogun Eruption (Drug eruption) jẹ iṣesi aifọkanbalẹ ti oogun lori awọ ara. Pupọ julọ awọn aami aisan awọ‑ara ti o fa oogun jẹ àìlera tó ń dínkù àti parí nígbà tí a bá dá oogun tí ó fa àìlera náà dúró. Sibẹsibẹ, àwọn àìlera tó ṣe pàtàkì jù lọ lè ní í ṣe pẹ̀lú ipalara ara bíi ẹdọ tàbí ibajẹ kidinrin. Àwọn oogun tún lè yí irun àti eekanna padà, nípa lílo àwọn membran mucous, tàbí fa ìkúnra (pruritus) láìsí àyípadà kankan lórí awọ ara.

Oògùn eruptions ń ṣe àyẹ̀wò nípa ìtàn àìlera àti ìṣèdá àyẹ̀wò. Biopsy awọ ara, àwọn ìdánwò ẹ̀jẹ̀ tàbí àyẹ̀wò ajẹsara lè wúlò.

Àpẹẹrẹ àwọn oogun tó wọ́pọ̀ tí ń fa eruption ni: àwọn oogun apakokoro àti àwọn oogun apakokoro míì, àwọn oogun sulfa, àwọn oogun egboogi‑iredodo tí kì í ṣe sitẹriọdu (NSAIDs), àwọn aṣoju kimoterapi fún àwọn àrùn àìlera, àwọn anticonvulsants, àti àwọn oogun psychotropic.

Ayẹwo àti Itọju
Ti o ba ní ìbà (ìgbóná ara tó pọ̀), ó yẹ kí o wá ìtọ́jú lẹ́sẹ̀kẹsẹ. Oogun tí a fura sí yẹ kí a dáwọ́ dúró (bí àpẹẹrẹ: àwọn oogun apakokoro, àwọn oogun egboogi‑iredodo tí kì í ṣe sitẹriọdu). Ṣáájú kí o lọ sí ilé‑ìwòsàn, antihistamines tí a máa ń jẹ́ ní ẹnu bí cetirizine tàbí loratadine lè ràn wọ́n lọ́wọ́ láti dín ìkúnra àti sísùn kù.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]

Idánwò ẹ̀jẹ̀ (CBC, LFT, iye eosinophil)
Awọn sitẹriọdu ẹnu àti antihistamines pẹ̀lú àṣẹ dọ́kítà.

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  • Oogun Eruption (Drug eruption) jẹ́ àfihàn nípa ipa tó ní lórí gbogbo ara.
  • Ni awọn iṣẹlẹ tí ó ní ipa púpọ̀ lórí ara, ayẹwo Oogun Eruption (Drug eruption) yẹ kí a gbero dipo kikan dermatitis.
  • AGEP (Acute generalized exanthematous pustulosis) jẹ iru iṣe ti oogun nfa.
References Current Perspectives on Severe Drug Eruption 34273058 
NIH
Awọn aati awọ-ara tí ó ṣẹlẹ̀ nípasẹ̀ oogun, tí a mọ̀ sí eruptions oogun, lè máa hàn nígbà míì. Àwọn aati lile wọ̀nyí, tí a ń pè ní severe cutaneous adverse drug reactions (SCARs), ni a kà sí eewu‑àyé. Wọ́n ní àwọn àìlera bí Stevens‑Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), àti drug reaction with eosinophilia and systemic symptoms (DRESS). Bí SCARs ṣe jẹ́ tójé, ní àyíká 2 % ti àwọn aláìsàn ilé‑ìwòsàn ní irírí wọn.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
 Fixed drug eruption - Case reports 35918090 
NIH
Arabinrin kan, ẹni ọdún mẹ́tàdínlógọ́rin, ṣàbẹ̀wò sí ẹ̀ka dermatology pẹ̀lú àpò pupa tí kò ní irora lórí òkè ẹsẹ̀ ọtún rẹ. Ó ti mu doxycycline (100 miligiramu) ní ọjọ́ kan ṣáájú, lẹ́yìn itọju laser picosecond fún àìlera irorẹ. Ní ọdún tó kọjá, ó tún ní àìlera tó jọ́ra ní ibùdó náà lẹ́yìn tí ó tún mu doxycycline (100 miligiramu) lẹ́ẹ̀kan sí i. Kò ní ìtàn àìlera pàtàkì, kò sì ní ààmì àìlera míì, bíi ìbà, ní agbègbè tàbí káàkiri ara rẹ.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
 Stevens-Johnson Syndrome 29083827 
NIH
Stevens-Johnson syndrome (SJS) ati toxic epidermal necrolysis (TEN) jẹ awọn ọna meji ti iṣesi awọ ara to ṣe pataki, ti o yato si awọn ipo awọ ara miiran bii erythema multiforme major ati staphylococcal scalded, ati awọn aati oogun. SJS/TEN jẹ iṣesi ti o ṣọwọn ati lile ti o nfa pipa awọ ara kaakiri ati ibajẹ awọn membran mucous, nigbagbogbo pẹlu awọn ami aisan eto. Ni diẹ ẹ̀ ju 80 % ti awọn ọran, oogun ni idi.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome­, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.