Panniculitis
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References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis ṣe akojọpọ oriṣiriṣi ti awọn arun iredodo ti o kan si ara adipose subcutaneous. Awọn ailera wọnyi ṣọwọn ninu awọn ọmọde. Panniculitis le jẹ ilana akọkọ ni rudurudu eto tabi ilana keji ti o jẹ abajade lati ikolu, ibalokanjẹ tabi ifihan si oogun. Pupọ julọ ti panniculitis ni igbejade ile-iwosan kanna (laibikita ti aetiology) , pẹlu tutu, awọn nodules subcutaneous erythematous.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , igbona ti ọra subcutaneous, nigbagbogbo ṣafihan pẹlu awọn nodules iredodo. Erythema nodosum (EN) ni ile-iwosan ti o wọpọ julọ ti panniculitis. Lakoko ti o to 55% ti EN jẹ idiopathic, awọn okunfa ti o wọpọ julọ pẹlu awọn akoran, awọn oogun, awọn aarun eto bii sarcoidosis ati arun ifun iredodo, oyun, ati aiṣedeede. EN ni igbagbogbo ṣafihan ni awọn ọdọ ati 20s, ati pe a rii ni igbagbogbo ni awọn obinrin. Nigbagbogbo o ṣaju nipasẹ ilana ti kii ṣe pato ti ọsẹ kan si mẹta, eyiti o le pẹlu iba, ailera, ati awọn aami aiṣan ti ikolu ti atẹgun oke. Awọn egbo awọ-ara lẹhinna tẹle, ni igbagbogbo ni agbegbe lori abala extensor ti awọn ẹsẹ. Awọn egbo naa jẹ irora yika tabi ofali, diẹ dide, awọn nodules pupa ti kii ṣe ọgbẹ. A ko loye pathogenesis gangan ti EN, botilẹjẹpe a ro pe o jẹ abajade lati ifisilẹ ti awọn eka ajẹsara ninu awọn ibi isere ti septae ni ọra subcutaneous, ti nfa panniculitis neutrophilic. Paapaa laisi itọju ailera kan pato fun ipo okunfa, EN ṣe ipinnu laisi itọju ni ọpọlọpọ awọn ọran.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
"Erythema nodosum" jẹ fọọmu ti panniculitis ti a ṣe afihan nipasẹ awọn nodules pupa tutu, 1-10 cm, ti o ni nkan ṣe pẹlu awọn aami aiṣan ti ara pẹlu iba, ailera, ati irora apapọ. Awọn nodules le dinku ni akoko ọsẹ 2-6 laisi ọgbẹ tabi ọgbẹ. Erythema nodosum ni nkan ṣe pẹlu awọn akoran, pẹlu Hepatitis C, EBV ati iko, oyun, lymphoma Non-Hodgkin, ati akàn pancreatic.