Syphilis
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Chancres ― akoran syphilitic akọkọ nipasẹ Treponema pallidum (Treponema pallidum)
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ReferencesSyphilis jẹ arun ti ibalopọ takọtabo ti o fa nipasẹ kokoro arun Treponema pallidum. Ninu iwadi yii, a fojusi awọn alaisan 57 ti ọjọ ori 18-68 pẹlu syphilis keji.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Syphilis jẹ akoran kokoro‑arun ti o fa nipasẹ Treponema pallidum. O le ṣe afihan awọn aami aisan ti ọpọlọpọ awọn arun miiran, ti a mọ̀ sí “great imitator”. Syphilis tun kan awọn miliọnu ni agbaye ṣugbọn a le ṣe itọju daradara pẹlu penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum fa syphilis nipasẹ ibalopọ ibalopo tabi lati ọdọ iya si ọmọ lakoko oyun. Paapaa botilẹjẹpe awọn idanwo ti o rọrun wa lati ṣe iwadii aisan rẹ ati itọju pẹlu iṣoogun penicillin kan ti o ṣiṣẹ pipẹ daradara, syphilis ti di iṣoro nla lẹẹkansii ni kariaye. Eyi jẹ otitọ paapaa laarin awọn ọkunrin ti o ni ibalopọ pẹlu awọn ọkunrin (MSM) ni awọn orilẹ-ede ti o ni owo‑wiwọle giga ati aarin. Lakoko ti diẹ ninu awọn orilẹ-ede ti owo‑wiwọle kekere ti pade awọn ibi‑afẹde WHO lati da syphilis ti a n kọja lati ọdọ iya si ọmọ, idaamu wa ni syphilis laarin MSM ti o ni arun HIV.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Ìtóbi ẹ̀dọ̀ (Hepatomegaly): Èyí sábà máa ń rí, ó sì lè ṣẹlẹ̀ pẹ̀lú ìtóbi àpò-ara (splenomegaly). Ìgbìmọ̀ biopsy ẹ̀dọ̀ labẹ́ microscopy àyè dudu lè ṣàfihàn wíwọ̀ spirochete. Àwọn ìdánwò iṣẹ́ ẹ̀dọ̀ lè fìhàn àìlera. (2) Jaundice (Ìyípo awọ̀): Jaundice lè wà tàbí kò wà, gẹ́gẹ́ bí ìpẹ̀yà ẹ̀dọ̀ ṣe pọ̀. (3) Rhinitis (ìbànújẹ́ imu): Nígbà míì, ó jẹ́ ọ̀kan lára àwọn àmi àkọ́kọ́, sábà máa hàn ní ọ̀sẹ̀ àkọ́kọ́ ti ìgbésí ayé. (4) Generalized Lymphadenopathy (Ìtìjú lymph gbogbogbo): Ìtìjú lymph gbogbogbo, tí kò ní irora, tún wà ní àpọ̀. (5) Rash (ìkó): Ìkó sábà máa hàn lẹ́yìn ọ̀sẹ̀ kan sí méjì lẹ́yìn rhinitis. Àwọn àpò pupa tàbí pinki kékeré lè wà lórí ẹ̀yìn, àyà, ẹ̀yìn-ìyà, àti àtẹlẹsẹ̀ ẹsẹ̀. Ìkó yìí lè ń lọ sí pípò àti ìkó‑ìdá.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Ayẹwo ati Itọju
VDRL ati RPR le ṣee lo lati jẹrisi ikolu laipe ati iboju fun syphilis. Idanwo FTA-ABS jẹ idanwo kan pato ati pe o le ṣee lo lati ṣayẹwo fun itan-akọọlẹ ikolu ti tẹlẹ. Penicillin ni a lo lati tọju syphilis.