Actinic keratosis is a pre-cancerous area of thick, scaly, or crusty skin. Actinic keratosis is a disorder of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure. These growths are more common in fair-skinned people and those who are frequently in the sun. They are believed to form when skin gets damaged by UV radiation from the sun or indoor tanning beds, usually over the course of decades. Given their pre-cancerous nature, if left untreated, they may turn into a type of skin cancer called squamous cell carcinoma. Untreated lesions have up to a 20% risk of progression to squamous cell carcinoma, so treatment by a dermatologist is recommended.
Actinic keratoses(老年性角化病或日光性角化病) 与长期日晒有关,常表现为受光部位的粗糙红色斑块。应尽早发现并开始治疗,因为若不及时处理,它们可能会发展为皮肤癌。 Actinic keratoses, also known as senile keratoses or solar keratoses, are benign intra-epithelial neoplasms commonly evaluated by dermatologists. Often associated with chronic sun exposure, individuals with actinic keratosis may present with irregular, red, scaly papules or plaques on sun-exposed regions of the body. Timely detection and implementation of a treatment plan are crucial since actinic keratosis can potentially progress into invasive squamous cell carcinoma.
Actinic keratoses(光化性角化病)是皮肤细胞的异常增生,具有转化为癌症的风险。它们常出现在长期日晒的皮肤部位,表现为平坦的斑点、凸起的肿块或粗糙的斑块,颜色多为淡红色。在早期阶段,触诊往往比目视检查更容易发现它们。 Actinic keratoses are dysplastic proliferations of keratinocytes with potential for malignant transformation. Clinically, actinic keratoses present as macules, papules, or hyperkeratotic plaques with an erythematous background that occur on photoexposed areas. At initial stages, they may be better identified by palpation rather than by visual inspection.
光化性角化病的典型表现为厚实、鳞屑或结痂的斑块,触感通常干燥、粗糙。病灶直径多在 2–6 毫米之间,亦可长至数厘米。值得注意的是,在肉眼尚未清晰看到病变前,常可通过触摸感受到其砂纸般的质地。
紫外线照射是光化性角化病的主要致因,病变常出现在曾被晒伤的皮肤以及长期日晒的部位,如面部、耳朵、颈部、头皮、胸部、手背、前臂或唇部。大多数患者常同时出现多个病灶。
当临床检查未出现典型特征,且仅凭外观无法排除原位或浸润性鳞状细胞癌(SCC)的可能时,需考虑进行活检或切除。
○ 诊断和治疗
#Dermoscopy
#Skin biopsy
#Cryotherapy
#5-FU
#Imiquimod