Acute generalized exanthematous pustulosis - 急性全身发疹性脓疱病https://en.wikipedia.org/wiki/Acute_generalized_exanthematous_pustulosis
急性全身发疹性脓疱病 (Acute generalized exanthematous pustulosis) (AGEP) 是一种罕见的皮肤反应,90% 的病例与用药有关。 急性全身发疹性脓疱病 (acute generalized exanthematous pustulosis) 的特征是开始用药后平均五天突然出现皮疹。这些皮疹是脓疱,即皮肤上出现红色、白色或红色的小皮疹,其中含有混浊或脓性物质(脓)。皮肤损伤通常会在停止用药后 1-3 天内消退。

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  • 突然出现广泛的红斑和脓疱皮损。
  • 突然出现红斑和脓疱,不痒。
References Acute Generalized Exanthematous Pustulosis 37276304 
NIH
Acute generalized exanthematous pustulosis (AGEP) 是一种皮肤反应,其特征是红色皮肤基底上出现充满脓液的小肿块。当某人服用某些药物(如抗生素)时,通常会发生这种情况,并迅速扩散到全身。停止触发药物后,症状通常会在两周内消失,通常会留下一些皮肤脱落。虽然通常并不严重且仅限于皮肤,但严重病例可以与其他严重皮肤反应一起分类,例如 Stevens-Johnson syndrome 或 toxic epidermal necrolysis 。治疗主要是支持性护理,疾病完全治愈的预后通常很好。
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
 Acute Generalized Exanthematous Pustulosis: Clinical Characteristics, Pathogenesis, and Management 36702114
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
 Acute Generalized Exanthematous Pustulosis - Case report 36876416 
NIH
一名76岁的男子因这两天皮肤出现变化而来到急诊室。医生在他的躯干、手臂和腿部发现了红色斑块和凸起区域。随着时间的推移,这些斑块连接在一起,他在红色区域出现了丘疹状的肿块。测试显示白细胞计数较高,其中含有大量中性粒细胞, C-reactive protein 水平升高。
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.