Amyloidosis - 淀粉样变性https://en.wikipedia.org/wiki/Amyloidosis
淀粉样变性 (Amyloidosis) 是一组异常蛋白质(称为淀粉样原纤维)在组织中积聚的疾病。患者常出现剧烈瘙痒的角化过度丘疹,丘疹可融合形成灰色至棕色斑块。常见受累部位为胫前部和上背部。

诊断和治疗
#Electrophoresis of blood or urine
#Skin biopsy
☆ 德国 Stiftung Warentest 2022 年的结果显示,消费者对 ModelDerm 的满意度仅略低于付费远程医疗咨询。
  • 淀粉样变性 (Amyloidosis)经典五官
  • 在放大视野中观察到形状相似的硬丘疹。它们相对均匀且坚硬,与特应性皮炎等过敏性疾病不同。
  • amyloidosis cutis dyschromica 的皮肤特征 ― (A) 小腿色素沉着过度和色素沉着不足的斑疹
  • Lichen amyloidosis 常被误诊为特应性皮炎。典型表现为小硬丘疹并伴有瘙痒。
  • 淀粉样变性 (Amyloidosis) 的病变可能类似于特应性皮炎。
References Lichen amyloidosis - Case reports 24130236 
NIH
一位26岁的女性来到我们的诊所,抱怨腿部已有10年的皮疹并伴有瘙痒。尽管使用了类固醇霜和他扎罗汀(tazarotene)霜,皮疹仍未好转。她没有任何相关的家族史。检查时,我们发现她大腿前侧有凸起且粗糙的斑块,这符合lichen amyloidosis的特征。
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
 Lichen Amyloidosis: Towards Pathogenesis-Driven Targeted Treatment 36763750 
NIH
Lichen Amyloidosis 是一种罕见的皮肤病,常伴有原因不明的持续性瘙痒。它通常表现为皮肤表面出现一簇簇凸起的变色斑块。Lichen Amyloidosis 多见于 50 至 60 岁的患者,但目前尚无根治方法。现有的治疗手段疗效普遍有限。
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
 Clinical Characteristics of Lichen Amyloidosis Associated with Atopic Dermatitis: A Single Center, Retrospective Study 38086357 
NIH
Lichen amyloidosis 是一种持久的皮肤瘙痒状况。它以主要出现在背部、小腿、大腿和手臂上的成簇增厚肿块而闻名。显微镜检查显示,Lichen amyloidosis 在皮肤表层有淀粉样蛋白堆积,同时表皮增厚、增大。虽然 Lichen amyloidosis 的确切原因尚不完全清楚,但已有研究将其与皮肤摩擦、细胞死亡、病毒感染等因素联系起来。Lichen amyloidosis 似乎与其他几种皮肤疾病有关,如 atopic dermatitis、lichen planus 和 mycosis fungoides。
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.