Amyloidosis - 淀粉样变性
amyloidosis cutis dyschromica 的皮肤特征 ― (A) 小腿色素沉着过度和色素沉着不足的斑疹
References
一位 26 岁的女性来到我们的诊所，抱怨她的腿上长了 10 年的皮疹，发痒。尽管使用了类固醇霜和他扎罗汀霜，皮疹仍然没有好转。她没有任何相关的家族史。当我们检查她时，我们发现她腿前部有凸起的粗糙斑块，这与一种名为 lichen amyloidosis 的疾病相符。
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis 是一种罕见的皮肤病，与不明原因的持续瘙痒有关。它通常表现为皮肤外表面上一簇簇凸起的变色斑块。 Lichen Amyloidosis 通常出现在 50 至 60 岁的人群中，不幸的是，无法治愈。现在可用的治疗方法通常效果不佳。
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis 是一种持久的皮肤瘙痒状况。它以主要出现在背部、小腿、大腿和手臂上的成簇增厚肿块而闻名。在显微镜下检查时， Lichen amyloidosis 显示皮肤表层有淀粉样蛋白堆积，同时外皮层增厚和增大。虽然 Lichen amyloidosis 的确切原因尚未完全清楚，但之前的研究已将其与皮肤摩擦或摩擦、细胞死亡、病毒感染等因素联系起来。 Lichen amyloidosis 似乎与其他几种皮肤状况有关，例如 atopic dermatitis, lichen planus, and mycosis fungoides 。
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ 诊断和治疗
#Electrophoresis of blood or urine
#Skin biopsy