Amyloidosis - 淀粉样变性
amyloidosis cutis dyschromica 的皮肤特征：（A）小腿出现色素沉着过度和色素缺乏的斑疹。
relevance score : -100.0%
References一位 26 岁的女性来到我们的诊所，抱怨腿部已有 10 年的皮疹并伴有瘙痒。尽管使用了类固醇霜和 tazarotene(他扎罗汀)霜，皮疹仍未好转。她没有任何相关的家族史。检查时，我们发现她腿前部有凸起的粗糙斑块，符合 lichen amyloidosis（淀粉样苔藓）的特征。
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis 是一种罕见的皮肤病，常伴有原因不明的持续性瘙痒。它通常表现为皮肤表面出现一簇簇凸起且颜色改变的斑块。Lichen Amyloidosis 多见于 50 至 60 岁的人群，遗憾的是目前尚无根治方法。现有的治疗手段疗效有限。
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis 是一种慢性皮肤瘙痒性疾病。它的特点是常见于背部、小腿、大腿和手臂，出现成簇的增厚结节。显微镜检查可见皮肤表层有淀粉样蛋白沉积，伴随表皮增厚和肥大。虽然 Lichen amyloidosis 的确切病因尚不完全清楚，但已有研究将其与皮肤摩擦或刺激、细胞凋亡、病毒感染等因素关联。Lichen amyloidosis 还常与其他皮肤疾病如 atopic dermatitis、lichen planus 和 mycosis fungoides 共存。
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ 诊断与治疗
#Electrophoresis of blood or urine
#Skin biopsy