Cellulitis - 蜂窝织炎
https://en.wikipedia.org/wiki/Cellulitis
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References
Cellulitis 31747177 NIH
Cellulitis 是一种常见的细菌性皮肤感染,每年影响美国超过 1400 万人,导致约 37 亿美元的门诊护理费用,并使约 65 万人住院治疗。通常,Cellulitis 表现为皮肤出现温暖、红色的区域,伴有肿胀和压痛。它由细菌的急性侵袭引起,使深层皮肤及邻近组织发生炎症,但不形成脓肿或脓液。β-溶血性链球菌,尤其是 A 组链球菌 (Streptococcus pyogenes),是最常见的致病菌,其次是 methicillin-sensitive Staphylococcus aureus。
Cellulitis is a common bacterial skin infection, with over 14 million cases occurring in the United States annually. It accounts for approximately 3.7 billion dollars in ambulatory care costs and 650000 hospitalizations annually. Cellulitis typically presents as a poorly demarcated, warm, erythematous area with associated edema and tenderness to palpation. It is an acute bacterial infection causing inflammation of the deep dermis and surrounding subcutaneous tissue. The infection is without an abscess or purulent discharge. Beta-hemolytic streptococci typically cause cellulitis, generally group A streptococcus (i.e., Streptococcus pyogenes), followed by methicillin-sensitive Staphylococcus aureus. Patients who are immunocompromised, colonized with methicillin-resistant Staphylococcus aureus, bitten by animals, or have comorbidities such as diabetes mellitus may become infected with other bacteria.
Cellulitis: current insights into pathophysiology and clinical management 29219814Cellulitis 是皮肤和软组织的细菌感染。当皮肤的保护屏障、免疫系统或血液循环出现问题时,就会发生这种情况。糖尿病、肥胖和老年通过影响这些因素,增加 cellulitis 的风险。我们还研究了近期对 cellulitis 的诊断发现,强调准确诊断的重要性,因为静脉功能不全、湿疹、深静脉血栓形成和痛风等疾病常与蜂窝组织炎混淆。用于治疗 cellulitis 的抗生素经过精心选择,以针对常见致病菌,同时避免促进抗生素耐药性。我们还讨论了批准用于 cellulitis 的新抗生素。Cellulitis 由于持续存在的风险因素和淋巴系统受损,常常复发。
Cellulitis is a bacterial infection of the skin and soft tissues. It happens when there are issues with the skin's protective barrier, the immune system, or blood circulation. Diabetes, obesity, and old age increase the chances of cellulitis by affecting these areas. We also look at recent findings on diagnosing cellulitis, highlighting the importance of accurate diagnosis since conditions like venous insufficiency, eczema, deep vein thrombosis, and gout are often confused with cellulitis. Antibiotics used to treat cellulitis are chosen carefully to target common bacteria without encouraging antibiotic resistance. We also talk about new antibiotics approved for cellulitis. Cellulitis often comes back because of ongoing risk factors and damage to the lymphatic system..
Current Treatment Options for Acute Skin and Skin-structure Infections 30957166 NIH
许多人因突发细菌性皮肤感染而前往医院或急诊室。Staphylococcus aureus 是导致这些感染的主要细菌,但某些菌株对常用抗生素具抗药性,使治疗日益困难。
Acute bacterial skin and skin-structure infections are a common reason for seeking care at acute healthcare facilities, including emergency departments. Staphylococcus aureus is the most common organism associated with these infections, and the emergence of community-associated methicillin-resistant Staphylococcus aureus (MRSA) has represented a considerable challenge in their treatment.
Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus 32257966 NIH
根据对抗生素的反应,Staphylococcus aureus 可分为两种类型:methicillin-sensitive Staphylococcus aureus (MSSA) 和 methicillin-resistant Staphylococcus aureus (MRSA)。过去几十年来,随着细菌进化和抗生素的过度使用,S. aureus 对药物的耐药性不断上升,导致全球 MRSA 感染率上升。
According to the sensitivity to antibiotic drugs, S. aureus can be divided into methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). In recent decades, due to the evolution of bacteria and the abuse of antibiotics, the drug resistance of S. aureus has gradually increased, the infection rate of MRSA has increased worldwide.
Treatment of severe skin and soft tissue infections: a review 29278528 NIH
To review the salient features of the management of severe skin and soft tissue infections (SSTIs), including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis.
最常见的受累部位是腿部和面部。危险因素包括肥胖、下肢水肿和老年。常见致病菌为链球菌和金黄色葡萄球菌。
治疗通常采用口服抗生素,例如 cefalexin (头孢氨苄)、amoxicillin (阿莫西林) 或 cloxacillin (氯唑西林)。约 95% 的患者在 7–10 天治疗后症状会明显好转。但糖尿病患者的预后往往较差。
蜂窝织炎是一种常见疾病,在英国约有 1.6% 的患者因该病住院。2015 年,全球因蜂窝织炎死亡约 16,900 人。
○ 治疗 - 非处方药
晚期蜂窝织炎必须使用医生开具的处方抗生素。如果病情进展迅速并伴有发热、寒战,应尽快就医。
在早期阶段,可在患处涂抹非处方抗生素软膏,但必须涂抹足够厚度,否则可能无效。
#Polysporin
#Bacitracin
#Betadine
可使用对乙酰氨基酚等非处方止痛药缓解疼痛。
#Ibuprofen
#Naproxen
#Acetaminophen
保持足部清洁并及时治疗脚气,因为脚气会增加蜂窝织炎的风险。
○ 治疗
#First‑generation cephalosporins (e.g. Cefradine)
#Bacterial culture
#Third‑generation cephalosporins (e.g. Cefditoren Pivoxil)