Intraepithelial carcinoma (Bowen disease) - 上皮内癌（Bowen 病）
典型病例 ― 上皮内癌（Bowen 病） (Intraepithelial carcinoma (Bowen disease)) 可能被误诊为持久、不痒的湿疹。
References
Bowen's disease (BD) 是一种从皮肤外层（表皮）开始的皮肤癌。它在白种人中更常见，通常发生在暴露于阳光的区域，但也可能出现在其他地方。 BD 通常表现为单个病变。 BD 通常被视为出现更严重的皮肤癌之前的警告信号。为了诊断双相情感障碍，医生通常依靠在显微镜下检查组织样本（活检）。
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease 主要影响 60 岁以上的白人。主要危险因素包括长期日晒、免疫系统减弱、砷暴露和皮肤 HPV 感染。 HPV 16、18、34 和 48 株与生殖器部位的鲍文氏病有关。 HPV 在非生殖器病例中的参与尚不清楚。
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
它通常表现为身体任何部位的红斑、鳞状或硬皮区域。最常见的位置是小腿。
它可以通过多种治疗方案治愈，例如冷冻疗法、刮除术、烧灼术、光动力疗法或病灶切除术。
○ 诊断和治疗
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy