Melasma - 黄褐斑
这是 40 岁出头的亚洲女性的常见病症。照片中圈出的病变更接近雀斑而不是黄褐斑。
References
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
最近， low-fluence Q-switched Nd:YAG (LFQSNY) 激光治疗黄褐斑变得流行，尤其是在亚洲。总结各种研究具有挑战性，但与传统疗法相比，LFQSNY 似乎对黄褐斑普遍有效且安全。然而，据报道，一些斑驳的色素减退病例是 LFQSNY 的副作用，可能是由于高激光能量造成的。过度使用 LFQSNY 还会导致炎症引起的色素沉着过度，尤其是深色肤色。
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
色素沉着问题经常在初级保健中发现。色素沉着过度疾病的常见类型包括 post-inflammatory hyperpigmentation, melasma, sunspots, freckles, and café au lait spots 。
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
黄褐斑是一种色素持续产生的疾病，不能通过一定时间的激光治疗来解决。氨烯酸有助于改善、减少色素沉着。
○ 治疗
在一些国家（例如日本、韩国），口服氨甲环酸可在柜台购买且有效。含有氨甲环酸和壬二酸的黄褐斑霜可能有部分帮助。
对苯二酚可局部用于治疗色素沉着过度，但 FDA 从 2020 年起停止销售含有对苯二酚的 OTC 产品。
#Tranexamic acid [TRANSINO]
#Laser toning technique (low fluence QS1064 laser)
#Triluma