Perioral dermatitis - 口周皮炎https://en.wikipedia.org/wiki/Perioral_dermatitis
口周皮炎 (Perioral dermatitis) 是面部常见的皮疹。症状包括多个小(1-2 毫米)肿块和水疱,有时伴有背景发红和鳞屑。病变仅限于口腔和鼻孔周围的皮肤。它可以是持续性的或复发性的,特别类似于酒渣鼻,在某种程度上也类似于痤疮和过敏性皮炎。

外用类固醇可能是导致这种情况的原因,保湿霜和化妆品也可能导致皮肤病的发展。治疗通常是停止外用类固醇和化妆品,在更严重的情况下,口服四环素。停止使用类固醇最初可能会使皮疹恶化。

据估计,发达国家每年有 0.5-1% 的人患有这种疾病。高达 90% 的受影响者是 16 岁至 45 岁之间的女性。

治疗 - 非处方药
口周皮炎往往是由化妆品慢性接触性皮炎引起的,因此不建议在口腔周围涂抹化妆品。服用非处方抗组胺药可能会有帮助。治疗通常需要几个月的时间。
#OTC antihistamine
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  • 口腔和鼻孔周围出现丘疹,背景发红,通常以口腔周围斑块或脓疱的形式观察到。
    References Perioral Dermatitis 30247843 
    NIH
    Perioral dermatitis 是一种常见于年轻女性的良性皮肤病,其特征是口腔周围出现红色小肿块或干燥、鳞状皮肤。虽然它通常影响口腔周围的区域,但它也可能出现在眼睛和鼻子附近,因此得名“口周皮炎”。在面部使用局部类固醇可能会引发这种情况,因此治疗的第一步通常是停止使用这些类固醇。其他治疗选择包括局部使用甲硝唑或钙调神经磷酸酶抑制剂,或口服四环素抗生素。口周皮炎通常对治疗反应良好,但有时会持续存在或反复复发。
    Perioral dermatitis is a benign eruption that occurs most commonly in young, female adults, consisting of small inflammatory papules and pustules or pink, scaly patches around the mouth. Although the perioral region is the most common area of distribution, this disease also can affect the periocular and paranasal skin. For this reason, it is often referred to as periorificial dermatitis. Topical steroid use to the face can trigger this, and therefore, a primary recommendation for treatment would be discontinuation of steroid application by the patient. Other treatment approaches include topical metronidazole, topical calcineurin inhibitors, and oral tetracycline antibiotics. Perioral dermatitis often responds readily to therapy but can be chronic and recurrent.
     Allergic contact cheilitis caused by propolis: case report 35195191 
    NIH
    蜂胶是蜜蜂从植物中提取的亲脂性物质。本病例报告的目的是展示该物质作为过敏性接触性唇炎病因的重要性。一名21岁女性患者主诉口周瘙痒湿疹5年。在过去的几个月里,它也影响了颈部。在诊断出接触性皮炎后,她接受了斑贴测试。斑贴试验结果显示蜂胶呈强阳性(++)。
    Propolis is a lipophilic resin extracted from plants by bees. The purpose of this case report was to show the importance of this substance as cause of allergic contact cheilitis. A 21-year-old female patient complained of pruritic perioral eczema for 5 years. In the past months it also affected the neck. After diagnosing contact dermatitis, she was submitted to a patch test with a Latin American baseline series. The result was strongly positive for propolis (++)
     Predictive Model for Differential Diagnosis of Inflammatory Papular Dermatoses of the Face 33911757 
    NIH
    以红斑丘疹为特征的各种炎症性皮肤病。临床常见病—— folliculitis and rosacea ;相对罕见的疾病 - eosinophilic pustular folliculitis (EPF) , granulomatous periorificial dermatitis (GPD) , and lupus miliaris disseminatus faciei (LMDF) 。
    Various inflammatory skin diseases characterized by erythematous papules that most often affect the face include clinically common folliculitis and rosacea, and relatively rare eosinophilic pustular folliculitis (EPF), granulomatous periorificial dermatitis (GPD), and lupus miliaris disseminatus faciei (LMDF).