Perioral dermatitis - 口周皮炎https://en.wikipedia.org/wiki/Perioral_dermatitis
口周皮炎 (Perioral dermatitis) 是面部常见的皮疹。症状包括多个直径 1‑2 毫米的小肿块和水疱,常伴有底层发红和鳞屑。病变仅局限于口唇和鼻孔周围的皮肤。可表现为持续性或复发性,临床上常与酒渣鼻相似,也可类似于痤疮或过敏性皮炎。

外用类固醇是常见诱因,保湿霜和化妆品亦可能促发。治疗首要措施是停用外用类固醇和化妆品;症状较重时可口服四环素。停用类固醇初期可能会使皮疹加重。

据估计,发达国家每年约有 0.5‑1% 的人患此病。约 90% 的患者为 16‑45 岁的女性。

治疗 - 非处方药
口周皮炎常因化妆品导致的慢性接触性皮炎而发作,故应避免在口周使用化妆品。服用非处方抗组胺药可能有帮助。治疗通常需要几个月的时间。
#OTC antihistamine
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  • 口腔和鼻孔周围出现丘疹,背景发红,通常以口腔周围斑块或脓疱的形式观察到。
    References Perioral Dermatitis 30247843 
    NIH
    Perioral dermatitis 是一种常见于年轻女性的良性皮肤病,特征是口腔周围出现红色小丘疹或干燥、鳞屑。虽然主要累及口周,但有时也可波及眼周和鼻旁,故称“口周皮炎”。使用局部类固醇可诱发此病,治疗首要措施是停用这些类固醇。其他治疗方案包括局部使用甲硝唑或钙调神经磷酸酶抑制剂,或口服四环素类抗生素。口周皮炎一般对治疗反应良好,但有时会持续或反复发作。
    Perioral dermatitis is a benign eruption that occurs most commonly in young, female adults, consisting of small inflammatory papules and pustules or pink, scaly patches around the mouth. Although the perioral region is the most common area of distribution, this disease also can affect the periocular and paranasal skin. For this reason, it is often referred to as periorificial dermatitis. Topical steroid use to the face can trigger this, and therefore, a primary recommendation for treatment would be discontinuation of steroid application by the patient. Other treatment approaches include topical metronidazole, topical calcineurin inhibitors, and oral tetracycline antibiotics. Perioral dermatitis often responds readily to therapy but can be chronic and recurrent.
     Allergic contact cheilitis caused by propolis: case report 35195191 
    NIH
    蜂胶是蜜蜂从植物中提取的亲脂性物质。本病例报告旨在展示该物质在过敏性接触性唇炎发病中的重要作用。一名21岁女性患者主诉口周瘙痒性湿疹5年,近几个月病变已波及颈部。诊断为接触性皮炎后,她接受了斑贴试验。试验结果显示蜂胶呈强阳性(++)。
    Propolis is a lipophilic resin extracted from plants by bees. The purpose of this case report was to show the importance of this substance as cause of allergic contact cheilitis. A 21-year-old female patient complained of pruritic perioral eczema for 5 years. In the past months it also affected the neck. After diagnosing contact dermatitis, she was submitted to a patch test with a Latin American baseline series. The result was strongly positive for propolis (++)
     Predictive Model for Differential Diagnosis of Inflammatory Papular Dermatoses of the Face 33911757 
    NIH
    以红斑丘疹为特征的各种炎症性皮肤病。临床常见病——folliculitis and rosacea;相对罕见的疾病——eosinophilic pustular folliculitis (EPF)、granulomatous periorificial dermatitis (GPD) 和 lupus miliaris disseminatus faciei (LMDF)。
    Various inflammatory skin diseases characterized by erythematous papules that most often affect the face include clinically common folliculitis and rosacea, and relatively rare eosinophilic pustular folliculitis (EPF), granulomatous periorificial dermatitis (GPD), and lupus miliaris disseminatus faciei (LMDF).