Prurigo nodularis - 痒疹疱疹
References
Prurigo nodularis 是一种持久的皮肤病，其特征是多个坚硬的肿块和结节，通常出现在手臂和腿部的外侧。这些肿块的颜色从肉色到粉红色不等，并且非常瘙痒。它们可以影响任何年龄段的人，并且通常与导致慢性瘙痒的其他皮肤病有关，例如特应性皮炎。治疗选择包括强效止痒药物、影响免疫系统的药物和针对神经系统的药物。治疗结节性痒疹通常需要长期治疗。
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
治疗通常包括在受影响的区域使用乳膏或注射类固醇。在更严重或顽固的情况下，可能需要光疗或抑制免疫系统的药物等治疗。沙利度胺和来那度胺是严重病例的选择，但它们可能会产生严重的副作用。与沙利度胺或来那度胺相比，较新的治疗方法（ opioid receptor antagonists, neurokinin-1 receptor antagonists ）显示出治疗结节性痒疹的前景，且副作用更少。
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo 是一种皮肤病，其特征是长期瘙痒（持续超过 6 周）、与抓伤相关的皮肤损伤以及经常抓伤的病史。它涉及皮肤的神经炎症和纤维化。
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis 是一种长期存在的皮肤问题，以发痒的结节为特征。我们不知道到底是什么原因造成的，但免疫和神经问题似乎在瘙痒-抓挠循环中发挥了作用。目前，美国 FDA 还没有批准任何专门针对结节性痒疹的治疗方法。
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ 治疗 - 非处方药
用肥皂清洗病变部位根本没有帮助，反而会使情况变得更糟。非处方类固醇软膏可能有助于缓解症状，但通常需要使用几周才能改善。继续服用抗组胺药也有助于缓解瘙痒。
#OTC steroid ointment
#OTC antihistamine
○ 治疗
#Intralesional triamcinolone injection