Prurigo nodularis - 痒疹疱疹
relevance score : -100.0%
ReferencesPrurigo nodularis 是一种慢性皮肤疾病，其特征为多个坚硬的肿块和结节，常见于手臂和腿部的外侧。这些肿块的颜色可从肉色到粉红色不等，且伴有强烈瘙痒。它可发生于任何年龄段，通常与导致慢性瘙痒的其他皮肤病（如特应性皮炎）有关。治疗选择包括强效止痒药物、影响免疫系统的药物以及针对神经系统的药物。治疗结节性痒疹通常需要长期治疗。
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
治疗通常包括在受影响的部位使用外用乳膏或注射类固醇。对于更严重或顽固的病例，可能需要光疗或免疫抑制剂等治疗。沙利度胺和来那度胺是严重病例的选择，但它们可能会产生显著的副作用。与沙利度胺或来那度胺相比，较新的治疗方法（opioid receptor antagonists, neurokinin-1 receptor antagonists）在治疗结节性痒疹方面显示出更好的前景，且副作用更少。
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo 是一种皮肤疾病，特征包括长期瘙痒（持续超过 6 周）、与抓伤相关的皮肤损伤以及反复抓挠的病史。该疾病涉及皮肤的神经炎症和纤维化。
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis(结节性痒疹)是一种慢性皮肤疾病，以瘙痒的结节为特征。其具体病因尚不明确，但免疫和神经因素似乎在瘙痒‑抓挠循环中起作用。目前，美国FDA尚未批准任何专门针对Prurigo nodularis(结节性痒疹)的治疗方法。
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ 治疗 - 非处方药
用肥皂清洗病变部位并无帮助，反而可能使情况恶化。非处方类固醇软膏可能有助于减轻症状，但通常需连续使用数周方可见效。继续服用抗组胺药也有助于缓解瘙痒。
#OTC steroid ointment
#OTC antihistamine
○ 治疗
#Intralesional triamcinolone injection