Toxic epidermal necrosis - 中毒性表皮坏死
特色脱皮中毒性表皮坏死 (Toxic epidermal necrosis)
References
Stevens-Johnson Syndrome (SJS) 和 Toxic Epidermal Necrolysis (TEN) 是皮肤出现大面积坏死和脱落的罕见情况。在治疗方面，环孢素对 SJS 非常有效，而静脉注射免疫球蛋白 (IVIg) 和皮质类固醇的组合对于 SJS 和 TEN 病例效果最好。
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) 是由某些药物和免疫系统活动引起的严重皮肤反应，导致外皮肤层（表皮）大规模脱离，影响身体表面30%以上。 TEN 的死亡率超过 20%，通常是由于感染和呼吸困难造成的。停止引起反应的药物、提供支持性护理以及使用额外的治疗可以改善结果。最近的研究表明，基于随机对照试验和多项研究的分析，环孢素、肿瘤坏死因子α抑制剂以及静脉注射免疫球蛋白和皮质类固醇的组合等药物可能会有所帮助。
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
最常见的原因是某些药物，如拉莫三嗪、卡马西平、别嘌呤醇、磺胺类抗生素和奈韦拉平。危险因素包括艾滋病毒和系统性红斑狼疮。治疗通常在医院进行，例如烧伤科或重症监护室。
○ 治疗
这是一种严重的疾病，因此如果您的嘴唇或嘴巴受到影响或者皮肤起水泡，请尽快去看医生。
可疑药物应停止使用。 （例如抗生素、非甾体抗炎药）