Of the 61 patients studied, hypersensitivity vasculitis (HSV) [23 (37.7%)] and Henoch Schonlein purpura (HSP) [16 (26.2%)] were the two most common forms. Systemic involvement was seen in 32 (52.45%) patients. Drugs were implicated in 12 (19.7%) cases, infections in 7 (11.4%) and connective tissue disorders in 4 (6.5%) cases. No association was seen between history of drug intake and tissue eosinophilia and also between histologically severe vasculitis and clinical severity.
Leukocytoclastic vasculitis 是一种影响皮肤深层小血管的皮肤炎症。它的发生可能没有任何已知原因,也可能与感染、肿瘤、自身免疫性疾病或药物有关。典型症状包括腿部出现红色或紫色斑点、小血管受累,并且在大约 30% 的病例中,身体的其他部位也会受到影响。大多数病例会在几周到几个月内自行痊愈。治疗方法根据病情的严重程度而有所不同,从逐渐减少口服皮质类固醇到使用其他无需类固醇即可减轻炎症的药物。 Leukocytoclastic vasculitis is a cutaneous, small-vessel vasculitis of the dermal capillaries and venules. This condition can be idiopathic or can be associated with infections, neoplasms, autoimmune disorders, and drugs. Key clinical features of leukocytoclastic vasculitis include palpable purpura on the lower extremity, small vessel involvement, and, in about 30 percent of individuals, extracutaneous involvement. Most cases of idiopathic cutaneous, small vessel vasculitis are self-limited with 90 percent of cases resolving in weeks to months of onset. Otherwise, treatment depends on the severity of disease and can range from an oral corticosteroid taper to various steroid-sparing immunosuppressive agents.
○ 诊断
仅限于皮肤的血管炎往往会随时间自行改善。但仍可通过血液和尿液检查筛查全身性或自身免疫性疾病。
○ 治疗 - 非处方药
若血管炎仅局限于皮肤且未累及其他器官,可使用类固醇软膏。
#OTC steroid ointment