Of the 61 patients studied, hypersensitivity vasculitis (HSV) [23 (37.7%)] and Henoch Schonlein purpura (HSP) [16 (26.2%)] were the two most common forms. Systemic involvement was seen in 32 (52.45%) patients. Drugs were implicated in 12 (19.7%) cases, infections in 7 (11.4%) and connective tissue disorders in 4 (6.5%) cases. No association was seen between history of drug intake and tissue eosinophilia and also between histologically severe vasculitis and clinical severity.
Leukocytoclastic vasculitis 是一种影响皮肤深层小血管的皮肤炎症。它的发生可能没有任何已知原因,也可能与感染、肿瘤、自身免疫性疾病或药物有关。典型症状包括腿部出现红色或紫色斑点、小血管受累,并且在大约 30% 的病例中,身体的其他部位也会受到影响。大多数病例会在几周到几个月内自行痊愈。治疗方法根据病情的严重程度而有所不同,从逐渐减少口服皮质类固醇到使用其他无需类固醇即可减轻炎症的药物。 Leukocytoclastic vasculitis is a cutaneous, small-vessel vasculitis of the dermal capillaries and venules. This condition can be idiopathic or can be associated with infections, neoplasms, autoimmune disorders, and drugs. Key clinical features of leukocytoclastic vasculitis include palpable purpura on the lower extremity, small vessel involvement, and, in about 30 percent of individuals, extracutaneous involvement. Most cases of idiopathic cutaneous, small vessel vasculitis are self-limited with 90 percent of cases resolving in weeks to months of onset. Otherwise, treatment depends on the severity of disease and can range from an oral corticosteroid taper to various steroid-sparing immunosuppressive agents.
○ 诊断
仅限于皮肤的血管炎可能会随着时间的推移而改善。然而,可以进行血液和尿液检查来检测全身性或自身免疫性疾病。
○ 治疗 - 非处方药
如果血管炎仅限于皮肤而没有侵犯其他器官,则可以使用类固醇软膏。
#OTC steroid ointment