Vitiligo - 白癜风
手指白癜风比其他部位的白癜风更难治疗。除了影响美观之外，白癜风是一种良性疾病，并且不会传染。在皮肤科，最有效的治疗方法是光疗或激光治疗（准分子），每周 2‑3 次，持续至少 1 年。如果您因经济原因或工作繁忙而无法经常就诊，可考虑使用经批准、适合家庭使用的光疗机。
眼睑白癜风
手上的白癜风
relevance score : -100.0%
References白癜风是一种常见的皮肤疾病，因黑色素细胞流失导致皮肤出现白斑。最近的研究表明，它是一种自身免疫性疾病。虽然通常被视为美容问题，但白癜风会严重影响患者的心理健康和日常生活。2011 年，专家将一种名为 segmental vitiligo 的类型单独分类于其他类型之外。
Vitiligo is a common skin disorder that causes patches of white skin due to the loss of melanocytes. Recent research shows it's an autoimmune disease. While it's often seen as a cosmetic issue, it can deeply affect mental well-being and daily life. In 2011, experts classified a type called segmental vitiligo separately from others.
Vitiligo is a common skin disorder that causes patches of white skin due to the loss of melanocytes. Recent research shows it's an autoimmune disease. While it's often seen as a cosmetic issue, it can deeply affect mental well-being and daily life. In 2011, experts classified a type called segmental vitiligo separately from others.
活动性白癜风患者有多种治疗选择，例如全身性糖皮质激素、光疗和全身性免疫抑制剂。稳定的白癜风患者可能通过局部皮质类固醇、局部钙调神经磷酸酶抑制剂、光疗和移植手术获得缓解。最近对白癜风潜在机制的认识取得了进展，推动了靶向治疗的发展。目前，JAK 抑制剂被认为最有前景，尽管与其他免疫抑制剂一样，存在激活潜伏感染和全身副作用的风险，但其耐受性良好，功能性疗效显著。正在进行的研究旨在明确参与白癜风发病的关键细胞因子（IFN-γ、CXCL10、CXCR3、HSP70i、IL-15、IL-17/23、TNF）。阻断这些因子已在动物模型及部分患者中展现出潜力。此外，miRNA‑based therapeutics 和 adoptive Treg cell therapy 的研究也在进行中。
Current models of treatment for vitiligo are often nonspecific and general. Various therapy options are available for active vitiligo patients, including systemic glucocorticoids, phototherapy, and systemic immunosuppressants. While stable vitiligo patients may benefit from topical corticosteroids, topical calcineurin inhibitors, phototherapy, as well as transplantation procedures. Recently, a better understanding of the pathophysiological processes of vitiligo led to the advent of novel targeted therapies. To date, JAK inhibitors are the only category that has been proved to have a good tolerability profile and functional outcomes in vitiligo treatment, even though the risk of activation of latent infection and systemic side effects still existed, like other immunosuppressive agents. Research is in progress to investigate the important cytokines involved in the pathogenesis of vitiligo, including IFN-γ, CXCL10, CXCR3, HSP70i, IL-15, IL-17/23, and TNF, the blockade of which has undergone preliminary attempts in animal models and some patients. In addition, studies on miRNA-based therapeutics as well as adoptive Treg cell therapy are still primary, and more studies are necessary.
Current models of treatment for vitiligo are often nonspecific and general. Various therapy options are available for active vitiligo patients, including systemic glucocorticoids, phototherapy, and systemic immunosuppressants. While stable vitiligo patients may benefit from topical corticosteroids, topical calcineurin inhibitors, phototherapy, as well as transplantation procedures. Recently, a better understanding of the pathophysiological processes of vitiligo led to the advent of novel targeted therapies. To date, JAK inhibitors are the only category that has been proved to have a good tolerability profile and functional outcomes in vitiligo treatment, even though the risk of activation of latent infection and systemic side effects still existed, like other immunosuppressive agents. Research is in progress to investigate the important cytokines involved in the pathogenesis of vitiligo, including IFN-γ, CXCL10, CXCR3, HSP70i, IL-15, IL-17/23, and TNF, the blockade of which has undergone preliminary attempts in animal models and some patients. In addition, studies on miRNA-based therapeutics as well as adoptive Treg cell therapy are still primary, and more studies are necessary.
目前尚无根治方法。对浅色皮肤患者，通常建议使用防晒霜和化妆品。其他治疗选择可能包括类固醇乳膏或光疗。
○ 治疗
#Phototherapy
#Excimer laser
#Tacrolimus ointment