Acute generalized exanthematous pustulosis - 急性全身發疹性膿皰病
急性全身發疹性膿皰病 (Acute generalized exanthematous pustulosis) (AGEP) 是一種罕見的皮膚反應，90% 的病例與用藥有關。 急性全身發疹性膿皰病 (acute generalized exanthematous pustulosis) 的特徵是開始用藥後平均五天突然出現皮疹。這些皮疹是膿皰，即皮膚上出現紅色、白色或紅色的小皮疹，其中含有混濁或膿性物質（膿）。皮膚損傷通常會在停止用藥後 1-3 天內消退。
突然出現廣泛的紅斑和膿皰皮損。
References
Acute generalized exanthematous pustulosis (AGEP) 是一種皮膚反應，其特徵是紅色皮膚基底上出現充滿膿液的小腫塊。當某人服用某些藥物（如抗生素）時，通常會發生這種情況，並迅速擴散到全身。停止觸發藥物後，症狀通常會在兩週內消失，通常會留下一些皮膚脫落。雖然通常不嚴重且僅限於皮膚，但嚴重病例可以與其他嚴重皮膚反應一起分類，例如 Stevens-Johnson syndrome 或 toxic epidermal necrolysis 。治療主要是支持性護理，疾病完全治癒的預後通常很好。
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
一名76歲的男子因這兩天皮膚出現變化而來到急診室。醫生在他的軀幹、手臂和腿部發現了紅色斑塊和凸起區域。隨著時間的推移，這些斑塊連接在一起，他在紅色區域出現了丘疹狀的腫塊。測試顯示白血球計數較高，其中含有大量中性粒細胞， C-reactive protein 水平升高。
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
