Amyloidosis - 澱粉樣變性
amyloidosis cutis dyschromica 的皮膚特徵 ― (A) 小腿色素沉著過度和色素沉著不足的斑疹
relevance score : -100.0%
References一位 26 歲的女性來到本診所，抱怨腿部已有 10 年的皮疹且伴有瘙癢。即使使用了類固醇霜和他扎羅汀霜，皮疹仍未改善。她沒有任何相關的家族史。檢查時，我們發現在她大腿前側有凸起且粗糙的斑塊，與名為 lichen amyloidosis 的疾病相符。
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis 是一種罕見的皮膚疾病，與原因不明的持續性搔癢相關。它通常表現為皮膚表面呈現一簇簇凸起且顏色異常的斑塊。Lichen Amyloidosis 多見於 50 至 60 歲的成人，遺憾的是目前尚無根治方法，現有的治療大多效果有限。
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis 是一種持續性的皮膚瘙癢狀況，主要出現在背部、小腿、大腿和手臂上，呈成簇的增厚結節。顯微鏡下觀察可見皮膚表層有澱粉樣蛋白沉積，伴隨表皮增厚與擴大。雖然 Lichen amyloidosis 的確切原因尚未完全明朗，但先前研究已將其與皮膚摩擦或刺激、細胞凋亡、病毒感染等因素相關聯。Lichen amyloidosis 似乎與其他幾種皮膚狀況有關，例如 atopic dermatitis、lichen planus 以及 mycosis fungoides。
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ 診斷與治療
#Electrophoresis of blood or urine
#Skin biopsy