Angiofibroma - 血管纖維瘤
relevance score : -100.0%
ReferencesCutaneous angiofibromas 可出現在身體的各個部位。於臉部時，常稱為纖維性丘疹或皮脂腺瘤；於陰莖時，稱為 pearly penile papules；於指甲下方，稱為甲週血管纖維瘤或 Koenen 腫瘤。口腔內則稱為口腔纖維瘤。臉部血管纖維瘤是 tuberous sclerosis (TS) 的突出特徵，TS 為影響皮膚、腎臟、心臟、大腦與肺部的遺傳性疾病。這些病變通常於 TS 患者的兒童期或成年早期出現在臉部。若有三個或以上臉部血管纖維瘤，或兩個或以上甲週血管纖維瘤，則對診斷 TS 具有重要意義。此外，某些情況下多個臉部血管纖維瘤可能與 multiple endocrine neoplasia type 1 (MEN‑1) 或 Birt‑Hogg‑Dubé syndrome 有關。Pearly penile papules 常見於陰莖的冠狀緣和溝部，為持續性、無痛的腫塊，較常見於未受割禮的男性。
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
1）臉部：Fibrous papule
2）陰莖：Pearly penile papule
3）指（趾）甲下方：Periungual angiofibroma