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Grover disease ，也稱為暫時性棘層松解性皮膚病，是一種皮疹，表現為上半身充滿液體的腫塊，主要發生在老年白人男性。通常會很癢，但不會持續很久。 Grover disease 有 4 種不同的組織變化模式，它與多種疾病有關，例如血癌。它可能很難追蹤和治療，因為它往往會自行出現和消失。由於 Grover disease 經常與其他皮膚病和非皮膚病皮膚病相關，因此排除其他伴隨疾病，包括造血系統惡性腫瘤至關重要。
Grover disease, also known as transient acantholytic dermatosis, is a rash that appears as bumps filled with fluid on the upper body, mainly in older white men. It's often itchy but doesn't last long. There are 4 different patterns of tissue changes in Grover disease, and it has been linked to various illnesses, like blood cancers. It can be hard to track and treat because it tends to come and go on its own. Because Grover disease has been associated frequently with other dermatologic and nondermatologic skin conditions, to rule out other concomitant disorders, including hematopoietic malignancies is essential.

This case report details a rare case of Grover's disease in an 80-year-old Caucasian male complaining of a rash across his chest over the last three to four months. The patient has a past medical history of essential hypertension, hyperlipidemia, osteoarthritis of the knee, chronic gastroesophageal reflux disease (GERD), supraventricular tachycardia, status post prostate cancer, and restless legs syndrome. During his initial evaluation, he was found to have a pruritic, erythematous, papular rash most notably along his upper trunk and chest. The patient utilized multiple lotions, emollients, and anti-itch creams with minimal relief of his symptoms and presentation. Following a referral to Dermatology, a biopsy of the rash was conducted, which revealed intraepidermal acantholysis, the hallmark finding for a diagnosis of Grover's disease. Subsequently, he was treated with a topical triamcinolone acetonide 0.1% cream for 14 days.