Intraepithelial carcinoma (Bowen disease) - 上皮內癌（Bowen 病）
典型病例 ― 上皮內癌（Bowen 病） (Intraepithelial carcinoma (Bowen disease)) 可能被誤診為持久、不癢的濕疹。
References
Bowen's disease (BD) 是一種從皮膚外層（表皮）開始的皮膚癌。它在白種人中更常見，通常發生在暴露於陽光的區域，但也可能出現在其他地方。 BD 通常表現為單一病變。 BD 通常被視為出現更嚴重的皮膚癌之前的警訊。為了診斷雙相情感障礙，醫生通常依靠在顯微鏡下檢查組織樣本（活檢）。
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease 主要影響 60 歲以上的白人。 HPV 16、18、34 和 48 株與生殖器部位的鮑文氏症有關。 HPV 在非生殖器病例中的參與尚不清楚。
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
它通常表現為身體任何部位的紅斑、鱗狀或硬皮區域。最常見的位置是小腿。
它可以透過多種治療方案治愈，例如冷凍療法、刮除術、燒灼術、光動力療法或病灶切除術。
○ 診斷與治療
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy