Keratoacanthoma - 角化棘皮瘤
典型 角化棘皮瘤 (Keratoacanthoma)
References
Keratoacanthoma (KA) 是一種常見的皮膚腫瘤，以其快速生長和自行消退的潛力而聞名。它通常發生在有曬傷史的年齡較大、皮膚白皙的男性身上。雖然使用切除或莫氏顯微手術進行手術切除是常用的治療方法，但還有各種其他治療選擇。
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) 是一種低度腫瘤，始於皮膚的某些腺體，在顯微鏡下看起來與 squamous cell carcinoma (SCC) 類似。關於 KA 是否應歸類為侵襲性鱗狀細胞癌的一種形式，一直存在爭論。
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Cutaneous squamous cell carcinoma (cSCC) 是人類第二常見的癌症類型，尤其是老年人。手術通常用於治療鱗狀細胞癌，但對於一些無法手術或選擇不手術的患者，可以考慮病灶內治療等其他選擇。傳統的病灶內治療 (methotrexate or 5-fluorouracil) 已被使用，但對病灶內免疫療法和溶瘤病毒療法等新方法的研究仍在進行中。在本文中，我們將研究 cSCC 的不同病灶內治療方法，從經典方法到前沿策略。
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
在顯微鏡下， 角化棘皮瘤 (keratoacanthoma) 與鱗狀細胞癌非常相似。雖然一些病理學家將 角化棘皮瘤 (keratoacanthoma) 歸類為一種獨特的實體而非惡性腫瘤，但約6% 的臨床和組織學 角化棘皮瘤 (keratoacanthoma) 確實進展為侵襲性和侵襲性鱗狀細胞癌。
○ 診斷與治療
#Dermoscopy
#Skin biopsy