Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen, and is only named that because it looks like one. It is characterized by polygonal, flat-topped, violaceous papules and plaques with overlying, reticulated, fine white scale, commonly affecting dorsal hands, flexural wrists and forearms, trunk, anterior lower legs and oral mucosa.
Lichen planus (LP) 是一種慢性發炎性疾病,主要影響中年成年人。它可出現在皮膚或黏膜上,如口腔、陰道、食道、喉部和眼瞼。根據皮疹的外觀與出現位置,LP 有不同的形式。研究顯示,某些類型的 LP,例如累及食道或眼睛的,可能難以充分診斷。某些形式的 LP,例如口腔中的肥厚型和糜爛型,往往特別造成負擔且持續時間較長。藥物或接觸特定物質等其他因素,也可能引發類似的皮疹。 Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP.
Lichen planus 是一種以紫色、平頂腫塊和斑塊為特徵的皮膚病,可引起劇烈搔癢。這些皮膚損傷可能令人痛苦,特別是當它們嚴重影響口腔或生殖器時。在嚴重的情況下,oral lichen planus 甚至可能增加皮膚癌的風險。它還會影響頭皮和指甲。雖然大多數病例的病因尚不清楚,但有些病例可能是由某些藥物或 C 型肝炎感染引發的。治療通常包括針對局部病例使用強效藥膏,針對更廣泛的病例使用口服類固醇。 Lichen planus is a skin condition marked by purplish, flat-topped bumps and patches that can cause intense itching. These skin lesions can be distressing, especially when they affect the mouth or genitals severely. In severe cases, oral lichen planus may even increase the risk of developing a type of skin cancer. It can also affect the scalp and nails. While the cause of most cases is unknown, some may be triggered by certain medications or hepatitis C infection. Treatment typically involves strong creams for localized cases and oral steroids for more widespread ones.
Lichen planus 是免疫系統引起發炎的情況,導致皮膚和黏膜上出現明顯的病變。它影響約 5% 的成年人,女性較常見,通常於中年開始發病。高達 77% 的患者口腔受累,最常見於內頰。部分患者可能無症狀,另一些則會感到疼痛,且在食用酸性或辛辣食物、使用某些牙膏時會感到不適。 Lichen planus is an immune-mediated inflammatory condition leading to characteristic lesions on skin and mucous membranes. It presents in up to 5% of the general adult population with a female predilection (2:1); the onset is most commonly in middle age. Up to 77% of patients with lichen planus have oral disease, with buccal mucosa the most common subsite. The oral lesions may be asymptomatic, although a subset of patients have pain and difficulty tolerating certain foods (e.g., acidic, spicy) and toothpaste.
確診皮膚扁平苔蘚可透過皮膚切片檢查。對於大皰性病變患者,亦可使用直接免疫螢光 (DIF) 以區分本病與自體免疫性水皰大皰性疾病。