Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen, and is only named that because it looks like one. It is characterized by polygonal, flat-topped, violaceous papules and plaques with overlying, reticulated, fine white scale, commonly affecting dorsal hands, flexural wrists and forearms, trunk, anterior lower legs and oral mucosa.
Lichen planus (LP) 是一種持久的發炎性疾病,主要影響中年成年人。它可以出現在皮膚或黏膜上,如口腔、陰道、食道、喉部和眼瞼。根據皮疹的外觀和出現位置,LP 有不同的形式。研究表明,某些類型的 LP,例如影響食道或眼睛的 LP,可能無法充分診斷。某些形式的 LP,例如口腔中的肥厚型和糜爛型,可能會特別造成負擔並持續很長時間。其他因素,如藥物或接觸某些物質,也可能引發類似的皮疹。 Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP.
Lichen planus 是一種以紫色、平頂腫塊和斑塊為特徵的皮膚病,可引起劇烈搔癢。這些皮膚損傷可能令人痛苦,特別是當它們嚴重影響口腔或生殖器時。在嚴重的情況下, oral lichen planus 甚至可能增加皮膚癌的風險。它還會影響頭皮和指甲。雖然大多數病例的病因尚不清楚,但有些病例可能是由某些藥物或C型肝炎感染引發的。治療通常包括針對局部病例使用強效藥膏,針對更廣泛的病例使用口服類固醇。 Lichen planus is a skin condition marked by purplish, flat-topped bumps and patches that can cause intense itching. These skin lesions can be distressing, especially when they affect the mouth or genitals severely. In severe cases, oral lichen planus may even increase the risk of developing a type of skin cancer. It can also affect the scalp and nails. While the cause of most cases is unknown, some may be triggered by certain medications or hepatitis C infection. Treatment typically involves strong creams for localized cases and oral steroids for more widespread ones.
Lichen planus 是免疫系統引起發炎的情況,導致皮膚和黏膜上出現明顯的痕跡。它影響大約 5% 的成年人,其中女性更常見,通常在中年左右開始。高達 77% 的病例可見口腔受累,主要影響內頰。雖然有些人可能沒有任何症狀,但其他人可能會感到疼痛,並對某些食物(例如酸性、辛辣)或牙膏有困難。 Lichen planus is an immune-mediated inflammatory condition leading to characteristic lesions on skin and mucous membranes. It presents in up to 5% of the general adult population with a female predilection (2:1); the onset is most commonly in middle age. Up to 77% of patients with lichen planus have oral disease, with buccal mucosa the most common subsite. The oral lesions may be asymptomatic, although a subset of patients have pain and difficulty tolerating certain foods (e.g., acidic, spicy) and toothpaste.
為了確診皮膚扁平苔蘚,可以進行皮膚切片檢查。直接免疫螢光 (DIF) 可用於大皰性病變患者,以區分此疾病與自體免疫性水皰大皰性疾病。