Lupus erythematosus - 紅斑狼瘡
relevance score : -100.0%
ReferencesCutaneous lupus erythematosus (CLE) 的識別與分類具有診斷挑戰，需與皮膚受累的 systemic lupus erythematosus 區分。最近的研究揭示了 CLE 的遺傳、環境及免疫因素。藥物誘發已成為 CLE 最重要的觸發因素之一。治療方式包括局部與全身治療，且有前景的生物製劑如 belimumab、rituximab、ustekinumab、anifrolumab 以及 BIIB059 已在臨床試驗中證實有效。
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) 包含多種皮膚表現，其中部分可能與全身性健康問題相關。它可分為不同類型，例如 acute CLE (ACLE)、sub‑acute CLE (SCLE) 以及 chronic CLE (CCLE)。其中，chronic CLE (CCLE) 包括 discoid lupus erythematosus (DLE)、LE profundus (LEP)、chilblain cutaneous lupus 以及 lupus tumidus。
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus 是一組可影響身體不同部位的自體免疫疾病。有些類型，如 systemic lupus erythematosus (SLE)，會波及多個器官；而其他類型，如 cutaneous lupus erythematosus (CLE)，則主要累及皮膚。我們依據臨床症狀、組織檢查與血液檢查對 CLE 的不同亞型進行分類，但個體之間差異甚大。皮膚問題通常與陽光曝曬、吸菸或某些藥物等因素有關。
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
紅斑狼瘡 (lupus erythematosus) 的病因尚未明確。研究顯示，同卵雙胞胎中若一方受影響，另一方有 24% 的機會亦會發病。女性性激素、陽光曝曬、吸菸、維生素 D 缺乏以及某些感染皆被認為會增加風險。
治療方式可能包括 NSAIDs(非類固醇抗發炎藥)、corticosteroids(皮質類固醇)、immunosuppressants(免疫抑制劑)、hydroxychloroquine(羥氯奎寧) 與 methotrexate(甲氨蝶呤)。雖然 corticosteroids(皮質類固醇) 確實有效，但長期使用可能導致副作用。