Melasma - 黃褐斑
這是 40 歲出頭的亞洲女性常見的疾病。照片中圈起來的病灶更接近雀斑而不是黃褐斑。
relevance score : -100.0%
ReferencesTranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
最近， low-fluence Q-switched Nd:YAG (LFQSNY) 雷射治療黃褐斑變得流行，尤其是在亞洲。總結各種研究具有挑戰性，但與傳統療法相比，LFQSNY 似乎對黃褐斑普遍有效且安全。然而，據報道，一些斑駁的色素減退病例是 LFQSNY 的副作用，可能是由於高雷射能量造成的。過度使用 LFQSNY 也會導致發炎引起的色素沉著過度，尤其是深色膚色。
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
色素沉澱問題常在基層醫療中被發現。常見的過度色素沉著疾病類型包括 post-inflammatory hyperpigmentation（發炎後色素沉著）、melasma（黃褐斑）、sunspots（日曬斑）、freckles（雀斑）以及 café au lait spots（咖啡牛奶斑）。
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
黃褐斑是一種色素持續產生的疾病，無法僅靠一定時間的雷射治療根除。tranexamic acid(氨甲環酸)有助於改善並減少色素沉澱。
○ 治療
在一些國家（例如日本、韓國），口服tranexamic acid(氨甲環酸)可在藥局購買且有效。含有tranexamic acid(氨甲環酸)和azelaic acid(壬二酸)的黃褐斑霜可能有部分幫助。hydroquinone(對苯二酚)可局部用於治療過度色素沉著，但 FDA 自 2020 年起已停止銷售含有hydroquinone(對苯二酚)的非處方產品。
#Tranexamic acid [TRANSINO]
#Laser toning technique (low fluence QS1064 laser)
#Triluma