Melasma - 黃褐斑
這是 40 歲出頭的亞洲女性常見的疾病。照片中圈起來的病灶更接近雀斑而不是黃褐斑。
References
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
最近， low-fluence Q-switched Nd:YAG (LFQSNY) 雷射治療黃褐斑變得流行，尤其是在亞洲。總結各種研究具有挑戰性，但與傳統療法相比，LFQSNY 似乎對黃褐斑普遍有效且安全。然而，據報道，一些斑駁的色素減退病例是 LFQSNY 的副作用，可能是由於高雷射能量造成的。過度使用 LFQSNY 也會導致發炎引起的色素沉著過度，尤其是深色膚色。
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
色素沉澱問題經常在初級保健中發現。色素沉著過度疾病的常見類型包括 post-inflammatory hyperpigmentation, melasma, sunspots, freckles, and café au lait spots 。
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
黃褐斑是一種色素持續產生的疾病，無法透過一定時間的雷射治療來解決。氨烯酸有助於改善、減少色素沉澱。
○ 治療
在一些國家（例如日本、韓國），口服氨甲環酸可在櫃檯購買且有效。含有氨甲環酸和壬二酸的黃褐斑霜可能有部分幫助。
對苯二酚可局部用於治療色素沉著過度，但 FDA 從 2020 年起停止銷售含有對苯二酚的 OTC 產品。
#Tranexamic acid [TRANSINO]
#Laser toning technique (low fluence QS1064 laser)
#Triluma