Perioral dermatitis - 口周皮炎https://en.wikipedia.org/wiki/Perioral_dermatitis
口周皮炎 (Perioral dermatitis) 是臉部常見的皮疹,症狀包括多個直徑 1–2 毫米的小腫塊或水皰,常伴有背景發紅與鱗屑。病灶僅限於口腔與鼻孔周圍的皮膚,可呈持續性或復發性,外觀上與酒渣鼻、痤瘡及過敏性皮膚炎有相似之處。

外用類固醇、保濕霜與化妝品皆可能誘發此狀況。治療的首要步驟是停止使用外用類固醇與化妝品,嚴重者可考慮口服四環素。停用類固醇初期可能會使皮疹暫時惡化。

據估計,已開發國家每年有 0.5% 至 1% 的人口會罹患此病,受影響者中高達 90% 為 16 歲至 45 歲的女性。

治療 - 非處方藥
口周皮炎往往是因化妝品引起的慢性接觸性皮膚炎,故不建議在口周使用化妝品。服用非處方抗組織胺可能有助緩解症狀。治療通常需要數個月的時間。
#OTC antihistamine
☆ 德國 Stiftung Warentest 2022 年的結果顯示,消費者對 ModelDerm 的滿意度僅略低於付費遠距醫療諮詢。
  • 口腔和鼻孔周圍出現丘疹,背景發紅,通常以口腔周圍斑塊或膿皰的形式觀察到。
    References Perioral Dermatitis 30247843 
    NIH
    Perioral dermatitis 是一種常見於年輕女性的良性皮膚病,其特徵是口腔周圍出現紅色小腫塊或乾燥、鱗狀的皮膚。雖然它通常影響口腔周圍的區域,但也可能出現在眼睛和鼻子附近,因此得名「口周皮膚炎」。在臉部使用局部類固醇可能會誘發此情況,治療的第一步通常是停止使用這些類固醇。其他治療選擇包括局部使用甲硝唑或鈣調神經磷酸酶抑制劑,或口服四環素類抗生素。口周皮膚炎大多對治療反應良好,但有時會持續或反覆復發。
    Perioral dermatitis is a benign eruption that occurs most commonly in young, female adults, consisting of small inflammatory papules and pustules or pink, scaly patches around the mouth. Although the perioral region is the most common area of distribution, this disease also can affect the periocular and paranasal skin. For this reason, it is often referred to as periorificial dermatitis. Topical steroid use to the face can trigger this, and therefore, a primary recommendation for treatment would be discontinuation of steroid application by the patient. Other treatment approaches include topical metronidazole, topical calcineurin inhibitors, and oral tetracycline antibiotics. Perioral dermatitis often responds readily to therapy but can be chronic and recurrent.
     Allergic contact cheilitis caused by propolis: case report 35195191 
    NIH
    蜂膠是蜜蜂從植物中提取的親脂性物質。本病例報告旨在說明該物質在過敏性接觸性唇炎中的致病重要性。一名21歲女性患者主訴口周搔癢濕疹已5年,近幾個月亦波及頸部。診斷為接觸性皮膚炎後,進行斑貼測試,結果顯示蜂膠呈強陽性(++)。
    Propolis is a lipophilic resin extracted from plants by bees. The purpose of this case report was to show the importance of this substance as cause of allergic contact cheilitis. A 21-year-old female patient complained of pruritic perioral eczema for 5 years. In the past months it also affected the neck. After diagnosing contact dermatitis, she was submitted to a patch test with a Latin American baseline series. The result was strongly positive for propolis (++)
     Predictive Model for Differential Diagnosis of Inflammatory Papular Dermatoses of the Face 33911757 
    NIH
    以紅斑丘疹為特徵的各種發炎性皮膚病。臨床常見的疾病包括毛囊炎 (folliculitis) 和酒糟鼻 (rosacea);相對罕見的疾病則有嗜酸性膿性毛囊炎 eosinophilic pustular folliculitis (EPF)、肉芽腫性口周皮炎 granulomatous periorificial dermatitis (GPD) 以及面部播散性黴菌瘤 lupus miliaris disseminatus faciei (LMDF)。
    Various inflammatory skin diseases characterized by erythematous papules that most often affect the face include clinically common folliculitis and rosacea, and relatively rare eosinophilic pustular folliculitis (EPF), granulomatous periorificial dermatitis (GPD), and lupus miliaris disseminatus faciei (LMDF).