Porokeratosis - 汗孔角化症
https://en.wikipedia.org/wiki/Porokeratosis
☆ 德國 Stiftung Warentest 2022 年的結果顯示,消費者對 ModelDerm 的滿意度僅略低於付費遠距醫療諮詢。 

堅硬的突出邊緣是其特徵。
relevance score : -100.0%
References
Porokeratosis 30335323 NIH
Porokeratosis 是一種罕見的皮膚病,其特徵是角化問題,導致皮膚上出現凸起的環形斑塊或粗糙的腫塊。其在顯微鏡下的顯著特徵是存在角質層,這是皮膚頂層細胞的特定排列。 Porokeratosis 有多種形式,例如 disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis 。值得注意的是, porokeratosis 有可能發展成皮膚癌。診斷 porokeratosis 的最佳方法是透過凸起邊界的活檢,儘管目前沒有標準的治療方案。
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated Superficial Actinic Porokeratosis 29083728 NIH
Disseminated superficial actinic porokeratosis (DSAP) 是一種角質化失調疾病。它是六種汗孔角化症之一,與其他類型相比,它通常影響更大的區域 (linear, Mibelli's, punctate, palmoplantar disseminated, and superficial porokeratosis) 。爆發性汗孔角化症通常與癌症、免疫力下降或發炎有關。危險因子包括遺傳、免疫抑制和陽光照射。 DSAP 最初是在暴露於陽光的區域出現粉紅色或棕色的腫塊,邊緣凸起,有時會引起輕微的搔癢。治療方法各不相同,可能包括外用乳膏、光療或 5-氟尿嘧啶或類維生素A 等藥物。這些病變被認為是癌前病變,有 7. 5 - 10 % 的機會轉變為鱗狀細胞癌或基底細胞癌。
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Porokeratosis of Mibelli - Case reports 33150040 NIH
一名 52 歲男子,之前身體健康,但他的第四個腳趾末端有一個扁平的環形斑塊,該斑塊已經存在兩年了,沒有引起任何症狀。它一開始是一個小而硬的腫塊,隨著時間的推移逐漸向外生長。儘管嘗試了冷凍療法、乳膏、抗真菌藥物和抗生素等各種治療方法,但貼片並沒有改善。透過皮膚鏡檢查仔細檢查,發現中心乾燥、紅色,邊緣厚而粗糙。從貼片邊緣取出的一小塊皮膚顯示皮膚外層有異常細胞生長,證實了 porokeratosis of Mibelli 的診斷。
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
通常會進行活檢,因為它看起來類似於光化性角化病或鱗狀細胞癌。