Prurigo nodularis - 痒疹
References
Prurigo nodularis 是一種持久的皮膚病，其特徵是多個堅硬的腫塊和結節，通常出現在手臂和腿部的外側。這些腫塊的顏色從肉色到粉紅色不等，並且非常發癢。它們可以影響任何年齡層的人，並且通常與其他導致慢性搔癢的皮膚病有關，例如異位性皮膚炎。治療選擇包括強效止癢藥物、影響免疫系統的藥物和針對神經系統的藥物。治療結節性癢疹通常需要長期治療。
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
治療通常包括在受影響的區域使用乳膏或註射類固醇。在更嚴重或頑固的情況下，可能需要光療或抑制免疫系統的藥物等治療。沙利度胺和來那度胺是嚴重病例的選擇，但它們可能會產生嚴重的副作用。與沙利度胺或來那度胺相比，較新的治療方法（ opioid receptor antagonists, neurokinin-1 receptor antagonists ）顯示出治療結節性癢疹的前景，且副作用較少。
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo 是一種皮膚病，其特徵是長期搔癢（持續超過 6 週）、與抓傷相關的皮膚損傷以及經常抓傷的病史。它涉及皮膚的神經發炎和纖維化。
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis 是一種長期存在的皮膚問題，以發癢的結節為特徵。我們不知道到底是什麼原因造成的，但免疫和神經問題似乎在搔癢-抓癢循環中發揮了作用。目前，美國 FDA 尚未批准任何專門針對結節性癢疹的治療方法。
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ 治療 - 非處方藥
用肥皂清洗病變部位根本沒有幫助，反而會讓情況變得更糟。非處方類固醇軟膏可能有助於緩解症狀，但通常需要使用幾週才能改善。繼續服用抗組織胺也有助於緩解搔癢。
#OTC steroid ointment
#OTC antihistamine
○ 治療
#Intralesional triamcinolone injection