Of the 61 patients studied, hypersensitivity vasculitis (HSV) [23 (37.7%)] and Henoch Schonlein purpura (HSP) [16 (26.2%)] were the two most common forms. Systemic involvement was seen in 32 (52.45%) patients. Drugs were implicated in 12 (19.7%) cases, infections in 7 (11.4%) and connective tissue disorders in 4 (6.5%) cases. No association was seen between history of drug intake and tissue eosinophilia and also between histologically severe vasculitis and clinical severity.
Leukocytoclastic vasculitis 是一種影響皮膚深層小血管的皮膚發炎。它的發生可能沒有任何已知原因,也可能與感染、腫瘤、自體免疫疾病或藥物有關。典型症狀包括腿部出現紅色或紫色斑點、小血管受累,在大約 30% 的病例中,身體的其他部位也會受到影響。大多數病例會在幾週到幾個月內自行痊癒。治療方法根據病情的嚴重程度而有所不同,從逐漸減少口服皮質類固醇到使用其他無需類固醇即可減輕發炎的藥物。 Leukocytoclastic vasculitis is a cutaneous, small-vessel vasculitis of the dermal capillaries and venules. This condition can be idiopathic or can be associated with infections, neoplasms, autoimmune disorders, and drugs. Key clinical features of leukocytoclastic vasculitis include palpable purpura on the lower extremity, small vessel involvement, and, in about 30 percent of individuals, extracutaneous involvement. Most cases of idiopathic cutaneous, small vessel vasculitis are self-limited with 90 percent of cases resolving in weeks to months of onset. Otherwise, treatment depends on the severity of disease and can range from an oral corticosteroid taper to various steroid-sparing immunosuppressive agents.
○ 診斷
僅限於皮膚的血管炎可能會隨著時間的推移而改善。然而,可以進行血液和尿液檢查來檢測全身性或自體免疫疾病。
○ 治療 - 非處方藥
如果血管炎僅限於皮膚而沒有侵犯其他器官,則可以使用類固醇軟膏。
#OTC steroid ointment