Vitiligo - 白癜風https://en.wikipedia.org/wiki/Vitiligo
☆ 德國 Stiftung Warentest 2022 年的結果顯示,消費者對 ModelDerm 的滿意度僅略低於付費遠距醫療諮詢。 Non-segmental vitiligo
白斑症有時會伴隨白髮。
relevance score : -100.0%
References Vitiligo: A Review 32155629白斑症是一種常見的皮膚病,由於黑色素細胞的流失而導致皮膚變白。最近的研究表明這是一種自體免疫疾病。雖然它通常被視為美容問題,但它會嚴重影響心理健康和日常生活。 2011年,專家將一種名為 segmental vitiligo 的類型與其他類型分開分類。
Vitiligo is a common skin disorder that causes patches of white skin due to the loss of melanocytes. Recent research shows it's an autoimmune disease. While it's often seen as a cosmetic issue, it can deeply affect mental well-being and daily life. In 2011, experts classified a type called segmental vitiligo separately from others.
Advances in vitiligo: Update on therapeutic targets 36119071 NIH
活動性白斑症患者有多種治療選擇,例如全身性糖皮質激素、光療和全身性免疫抑制劑。穩定的白斑症患者可能會因局部皮質類固醇、局部鈣調神經磷酸酶抑制劑、光療和移植手術而得到緩解。最近在了解白斑潛在過程方面取得的進展促進了標靶治療的發展。目前,JAK 抑制劑是最有前途的,儘管與其他免疫抑制劑一樣存在激活潛伏感染和全身副作用的風險,但它具有良好的耐受性和功能結果。正在進行的研究旨在確定參與白斑症發展的關鍵細胞因子 (IFN-γ, CXCL10, CXCR3, HSP70i, IL-15, IL-17/23, TNF) 。阻斷這些細胞因子已在動物模型和一些患者中顯示出希望。此外,對 miRNA-based therapeutics 和 adoptive Treg cell therapy 的調查正在進行中。
Current models of treatment for vitiligo are often nonspecific and general. Various therapy options are available for active vitiligo patients, including systemic glucocorticoids, phototherapy, and systemic immunosuppressants. While stable vitiligo patients may benefit from topical corticosteroids, topical calcineurin inhibitors, phototherapy, as well as transplantation procedures. Recently, a better understanding of the pathophysiological processes of vitiligo led to the advent of novel targeted therapies. To date, JAK inhibitors are the only category that has been proved to have a good tolerability profile and functional outcomes in vitiligo treatment, even though the risk of activation of latent infection and systemic side effects still existed, like other immunosuppressive agents. Research is in progress to investigate the important cytokines involved in the pathogenesis of vitiligo, including IFN-γ, CXCL10, CXCR3, HSP70i, IL-15, IL-17/23, and TNF, the blockade of which has undergone preliminary attempts in animal models and some patients. In addition, studies on miRNA-based therapeutics as well as adoptive Treg cell therapy are still primary, and more studies are necessary.
白斑症尚無已知的治療方法。對於淺色皮膚的人來說,通常建議使用防曬霜和化妝品。其他治療選擇可能包括類固醇乳膏或光療。
○ 治療
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