Ulwazi olwengeziwe ― Zulu

Owesifazane oneminyaka engu-26 weza emtholampilo wethu ekhala ngokuluma emilenzeni abeseneminyaka engu-10 enawo. Naphezu kokusebenzisa okhilimu be-steroid kanye nokhilimu we-tazarotene, ukuqubuka akuzange kube ngcono. Wayengenawo umlando womndeni ohlobene. Lapho simhlola, sathola amabala aphakeme, amaholoholo ngaphambili emilenzeni, afana nesifo esibizwa ngokuthi lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.

I- Lichen Amyloidosis yisimo sesikhumba esingavamile esixhunyaniswa nokulunywa okuqhubekayo kwembangela engaziwa. Ivamise ukubonakala njengamaqoqo amabala aphakanyisiwe, ashintshe umbala endaweni engaphandle yesikhumba. Lichen Amyloidosis ngokuvamile ivela kubantu abaneminyaka engu-50 kuya ku-60 futhi ngeshwa, alikho ikhambi lakho. Ukwelashwa okutholakalayo manje akuvamile ukusebenza kahle.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.

Lichen amyloidosis yisimo sesikhumba esiluma isikhathi eside. Yaziwa ngamaqoqo amaqhubu ajiyile atholakala ikakhulukazi emhlane, ezinqeni, emathangeni nasezingalweni. Uma ihlolwa ngaphansi kwesibonakhulu, i- Lichen amyloidosis ibonisa ukunqwabelana kwe-amyloid ongqimbeni olungaphezulu lwesikhumba kanye nokujiya nokwandiswa kongqimba lwesikhumba olungaphandle. Nakuba imbangela yangempela ye- Lichen amyloidosis ingakaqondwa ngokugcwele okwamanje, izifundo zangaphambilini ziyixhumanise nezinto ezifana nokuhlikihla noma ukungqubuzana esikhumbeni, ukufa kwamangqamuzana, izifo ezibangelwa amagciwane, phakathi kokunye. I- Lichen amyloidosis ibonakala ixhunywe nezinye izimo zesikhumba ezimbalwa (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.