Syphilis - Ugcunsula
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Emiphumeleni ka-2022 ye-Stiftung Warentest evela eJalimane, ukwaneliseka kwabathengi nge-ModelDerm bekungaphansi kancane kunokuxhumana okukhokhelwayo kwe-telemedicine.
Emiphumeleni ka-2022 ye-Stiftung Warentest evela eJalimane, ukwaneliseka kwabathengi nge-ModelDerm bekungaphansi kancane kunokuxhumana okukhokhelwayo kwe-telemedicine.
Chancres — ukutheleleka kokuqala kwesifilisi okubangelwa i‑Treponema pallidum
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ReferencesI-Syphilis yisifo esithathelwana ngocansi esibangelwa i-bacterium Treponema pallidum. Kulolu cwaningo, sigxile ezigulini ezingama-57 ezineminyaka engu-18 kuya ku-68 ezine-syphilis yesibili.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
ISyphilis ukutheleleka okubangelwa ibhaktheriya i‑Treponema pallidum. Ingakwazi ukulingisa izifo ezihlukahlukene, ngakho ithola igama lesidlaliso elithi “great imitator”. ISyphilis isathinta izigidi zabantu emhlabeni jikelele, kodwa ingelashwa ngempumelelo nge‑penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
UTreponema pallidum ibanga ugcunsula ngokuthintana nocansi noma ngokudluliselwa kusuka kumama kuye enganeni ngesikhathi sokukhulelwa. Nakuba kukhona ukuhlola okulula kokuthola lesi sifo kanye nokwelashwa ngepenicillin eyodwa esebenza isikhathi eside, ugcunsula useluyinkinga enkulu emhlabeni jikelele. Lokhu kuyiqiniso ikakhulukazi kwabesilisa abathanda ucansi nabesilisa (MSM) ezindaweni ezinezimali eziphakeme naphakathi. Ngenkathi amazwe anemali ephansi ehlangabezana nezinjongo ze-WHO zokumisa ukutheleleka kusuka kumama kuye enganeni, kukhona ukukhuphuka okukhathazayo kokutheleleka phakathi kwama-MSM anegciwane le-HIV.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Isibindi esinwetshiwe: Lokhu kuvame ukutholakala futhi kungase kwenzeke eduze kobende olukhulisiwe. Ukuhlola i‑biopsy yesibindi ngaphansi kwe‑darkfield microscopy kungase kwembule ubukhona be‑spirochete. Ukuhlolwa kokusebenza kwesibindi kungase kubonise okungavamile. (2) Ukuba phuzi kwesikhumba (Ijaundice): Ukuthi umuntu ubonisa i‑Ijaundice kuncike ekutheni isibindi sithinteke kangakanani. (3) Ikhala eligijima: Ngokuvamile uphawu lokuqala, luvame ukuvela phakathi nesonto lokuqala ngemva kokuzalwa. (4) Ama‑lymph nodes avuvukile: Ukuvuvukala okujwayelekile kwama‑lymph nodes, ngokuvamile okungenabuhlungu, kuvamile. (5) Ukuqubuka kwesikhumba: Ukuqubuka kuvame ukuvela isonto elilodwa noma amabili ngemva kwekhala eligijima. Ungabona izindawo ezincane ezibomvu noma ezibomvana ngemuva, ezinqeni, emathangeni nasezinyaweni. Lokhu kuqubuka kungaqhubeka nokuxebuka nokuhlangana.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Ukuxilongwa Nokwelashwa
I‑VDRL ne‑RPR zingasetshenziswa ukuze kuqinisekiswe ukutheleleka kwakamuva kanye nokuhlola ugcunsula. Ukuhlolwa kwe‑FTA‑ABS kuwukuhlola okuqondile futhi kungasetshenziswa ukuhlola umlando wokutheleleka wangaphambilini. I‑penicillin isetshenziselwa ukwelapha i‑syphilis.